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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2025; 31(41): 112642
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.112642
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.112642
RGS4 in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression
Yun Yang, College of Clinical Medicine, Shandong Second Medical University, Weifang 261042, Shandong Province, China
Yun Yang, Wen-Ming Chen, Department of Oncology, Jining No. 1 People’s Hospital, Jining 272011, Shandong Province, China
Author contributions: Yang Y wrote the original draft of the manuscript, and designed the schematic diagram illustrating the mechanism; Chen WM supervised the study and reviewed and edited the manuscript; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Ming Chen, MD, Associate Chief Physician, Department of Oncology, Jining No. 1 People’s Hospital, No. 6 Jiankang Road, Jining 272011, Shandong Province, China. yusuker9950529@163.com
Received: August 7, 2025
Revised: September 10, 2025
Accepted: September 28, 2025
Published online: November 7, 2025
Processing time: 92 Days and 7 Hours
Revised: September 10, 2025
Accepted: September 28, 2025
Published online: November 7, 2025
Processing time: 92 Days and 7 Hours
Core Tip
Core Tip: Chen et al provided compelling multilevel evidence that regulator of G-protein signaling 4 drives gastric cancer progression through focal adhesion kinase/phosphoinositide 3-kinase/protein kinase B activation and epithelial-mesenchymal transition, combining clinical correlation with functional validation. Although further mechanistic studies and expanded clinical cohorts would strengthen the findings, this work establishes G-protein signaling 4 as a promising the