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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2025; 31(40): 111375
Published online Oct 28, 2025. doi: 10.3748/wjg.v31.i40.111375
Published online Oct 28, 2025. doi: 10.3748/wjg.v31.i40.111375
Role of gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease
Aneta Sokal-Dembowska, Sara Jarmakiewicz-Czaja, Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, Rzeszow 35-959, Poland
Kübra Ergan, Department of Nutrition and Dietetics, Istanbul Yeni Yuzyil University, Istanbul 34010, Türkiye
Kübra Ergan, Department of Nutrition and Dietetics, Istinye University Graduate School of Education, Istanbul 34485, Türkiye
Author contributions: Sokal-Dembowska A and Jarmakiewicz-Czaja S contributed equally to this work; Sokal-Dembowska A and Jarmakiewicz-Czaja S conceptualized, conceived, supervised and critically revised the paper; Sokal-Dembowska A, Ergan K, Jarmakiewicz-Czaja S conducted the literature review, analyzed, interpreted the data and prepared the original manuscript; All authors drafted and approved the submitted version.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sara Jarmakiewicz-Czaja, PhD, Researcher, Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, Kopisto 2a, Rzeszow 35-959, Poland. sjczaja@ur.edu.pl
Received: July 1, 2025
Revised: July 30, 2025
Accepted: September 16, 2025
Published online: October 28, 2025
Processing time: 121 Days and 14.4 Hours
Revised: July 30, 2025
Accepted: September 16, 2025
Published online: October 28, 2025
Processing time: 121 Days and 14.4 Hours
Core Tip
Core Tip: Metabolic dysfunction-associated steatotic liver disease (MASLD) in inflammatory bowel disease (IBD) may share a common denominator with the gut microbiota. Through various factors, such as environmental factors, intestinal dysbiosis can occur, disrupting the homeostasis of the intestinal barrier and the entry of, for example, bacterial metabolites that exacerbate inflammation in the body. In the review, we analysed the various pathogenetic mechanisms of MASLD in IBD with an emphasis on the role of the gut microbiota.