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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2025; 31(40): 110932
Published online Oct 28, 2025. doi: 10.3748/wjg.v31.i40.110932
Published online Oct 28, 2025. doi: 10.3748/wjg.v31.i40.110932
Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study
Min Woo Lee, In Rae Cho, Jin Ho Choi, Woo Hyun Paik, Ji Kon Ryu, Sang Hyub Lee, Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, South Korea
Jin Myung Park, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24289, South Korea
Kwang Hyun Chung, Department of Internal Medicine, Soon Chun Hyang University Hospital, Seoul 04401, South Korea
Bong Seong Kim, Kyungdo Han, Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, South Korea
Co-first authors: Min Woo Lee and Jin Myung Park.
Co-corresponding authors: Kyungdo Han and Sang Hyub Lee.
Author contributions: Lee MW and Park JM contributed equally as co-first authors, participated in the formal analysis, investigation, and wrote the original draft; Kim BS and Han K were responsible for developing the methodology; Cho IR, Chung KH, Choi JH, Paik WH, Ryu JK, Han K, and Lee SH participated in the review and editing; Han K and Lee SH designed the study and acquired funding, contributed equally as co-corresponding authors. All authors approved the final version to publish.
Institutional review board statement: This study was approved by the Institutional Review Board of Seoul National University Hospital, No. H-2406-052-1542.
Informed consent statement: The information on the subjects stored in the database was de-identified before the researchers accessed the data. Therefore, informed consent was waived for this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sang Hyub Lee, MD, PhD, Professor, Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea.
Received: June 19, 2025
Revised: July 29, 2025
Accepted: September 16, 2025
Published online: October 28, 2025
Processing time: 130 Days and 17.2 Hours
Revised: July 29, 2025
Accepted: September 16, 2025
Published online: October 28, 2025
Processing time: 130 Days and 17.2 Hours
Core Tip
Core Tip: Gamma-glutamyl transferase (GGT), a marker of oxidative stress and hepatic dysfunction, has been reported to be associated with metabolic diseases and malig