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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2025; 31(39): 110115
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110115
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110115
Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis
Xin-Xing Wang, Long-Fei Dai, Shuai Shao, Xian-Wen Xu, Ru-Xin Gao, Department of Hepato
Ming-Ze Ma, Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Li-Chao Zhu, Department of Pediatric Surgery, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China
Chuan Qin, Department of Hepatobiliary Surgery, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China
Zhen-Hai Zhang, Department of Hepatobiliary Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China
Co-first authors: Xin-Xing Wang and Ming-Ze Ma.
Author contributions: All authors participated in the design, interpretation of the studies and analysis of the data and review of the manuscript; Wang XX and Ma MZ drafted the work and revised it critically for important intellectual content; Zhu LC, Dai LF, Qin C, Shao S, Xu XW and Gao RX were responsible for the acquisition, analysis and interpretation of data for the work; Wang XX, Ma MZ and Zhang ZH made substantial contributions to the conception or design of the work; All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82000579 and No. 81870205; and Natural Science Foundation of Shandong Province, No. ZR2021QH061 and No. ZR2021QH186.
Institutional animal care and use committee statement: The animal study was approved by the Experimental Animal Welfare Ethics Committee of MDKN Biotechnology Co., Lt (Approval No. MDKN-2024-129). All methods were carried out in accordance with relevant guidelines and regulations.
Conflict-of-interest statement: The authors declare that they have no competing interests.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Hai Zhang, Department of Hepatobiliary Surgery, Shandong Provincial Hospital, Shandong University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. drzhangzhenhai@163.com
Received: May 30, 2025
Revised: July 11, 2025
Accepted: September 15, 2025
Published online: October 21, 2025
Processing time: 145 Days and 7.2 Hours
Revised: July 11, 2025
Accepted: September 15, 2025
Published online: October 21, 2025
Processing time: 145 Days and 7.2 Hours
Core Tip
Core Tip: Cholelithiasis is a common biliary disorder with complex mechanisms. Lysine succinylation, a protein post-translational modification, remains unstudied in this condition. This study reveals that lysine acetyltransferase 2A-mediated su