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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2025; 31(38): 111363
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.111363
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.111363
Clip-assisted endoscopic cyanoacrylate injection vs endoscopic ultrasound-guided coil and cyanoacrylate injection for gastric varices: A propensity score-matched study
Yang-Yang Xiong, Di-Wu Li, Tian-Yu Zhou, Han Ma, Jian-Guo Gao, Zhe Shen, Cheng-Fu Xu, Chao-Hui Yu, Department of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Xiong YY, Shen Z, Xu CF and Yu CH designed the trial; Xiong YY, Li DW and Zhou TY collected the data; Ma H and Gao JG analyzed the data; Xiong YY drafted the manuscript; Xu CF and Yu CH supervised the entire process.
Supported by the National Natural Science Foundation of China, No. 82200664; and the Clinical Research Program of The First Affiliated Hospital, Zhejiang University School of Medicine, No. BL2025023.
Institutional review board statement: This retrospective study was approved by the Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine (No. 2024IIT803).
Informed consent statement: This study was a retrospective cohort analysis. The information and data involved posed no risk to the patients. In accordance with the requirements of the Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine, the need for informed consent was waived. Please refer to the ethics approval document for details.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The original data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao-Hui Yu, MD, Doctor, Department of Gastroenterology, Zhejiang Provincial Clinical Research Centre for Digestive Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn
Received: June 30, 2025
Revised: July 30, 2025
Accepted: September 1, 2025
Published online: October 14, 2025
Processing time: 108 Days and 17.1 Hours
Revised: July 30, 2025
Accepted: September 1, 2025
Published online: October 14, 2025
Processing time: 108 Days and 17.1 Hours
Core Tip
Core Tip: This propensity score-matched study compared clip-assisted endoscopic cyanoacrylate injection (Clip-CYA) and endoscopic ultrasound-guided coil and cyanoacrylate injection (EUS-CG) for gastric varices (GVs) with spontaneous portosystemic shunts. Both methods achieved comparable efficacy and safety. However, Clip-CYA required significantly less procedure time and cost, even in patients with large varices (> 3 cm). These findings suggest that Clip-CYA may serve as a more efficient and accessible alternative to EUS-CG in the emergency and real-world treatment of bleeding GVs.