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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2025; 31(38): 109528
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.109528
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.109528
Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study
Xiao-Feng Hu, Department of Oncology, Guangyuan Central Hospital, Guangyuan 628000, Sichuan Province, China
Xiang-Jun Dong, Xiang-Wen Xia, Hong-Jie Fan, Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Xin-Yue Gu, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Ji-Hong Hu, Department of Minimally Invasive Intervention, The First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China
Xing-Hai Li, Department of Minimally Invasive Intervention, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi Province, China
Fen-Hua Zhao, Department of Radiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang 322100, Zhejiang Province, China
Shu-Feng Xu, Department of Radiology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang Province, China
Co-first authors: Xiao-Feng Hu and Xiang-Jun Dong.
Co-corresponding authors: Hong-Jie Fan and Shu-Feng Xu.
Author contributions: Xu SF and Fan HJ made substantial contributions to the study’s conception and design; Hu XF, Gu XY, Xia XW, Hu JH, Li XH, and Xu SF were responsible for material preparation, data collection, and analysis; The initial draft of the manuscript was prepared by Hu XF; Hu XF and Zhao FH were responsible for data curation, formal analysis, investigation, conceptualization, and manuscript review and editing; Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF reviewed and approved the final submitted version.
Supported by the National Natural Science Foundation of China, No. 82302332 and No. 82272100; and Guiding Science and Technology Research Project of Quzhou, No. ZD2022020.
Institutional review board statement: This study was approved by the Ethics Review Committee of our hospital (No. IEC-2024-1130). All procedures were conducted in accordance with the ethical standards of the responsible committee on human experimentation and the Declaration of Helsinki.
Informed consent statement: Due to the retrospective nature of the study, the requirement for informed consent was waived.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Feng Xu, MD, Doctor, Department of Radiology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, No. 100 Minjiang Avenue, Kecheng District, Quzhou 324000, Zhejiang Province, China.
Received: May 15, 2025
Revised: June 17, 2025
Accepted: September 1, 2025
Published online: October 14, 2025
Processing time: 152 Days and 18.2 Hours
Revised: June 17, 2025
Accepted: September 1, 2025
Published online: October 14, 2025
Processing time: 152 Days and 18.2 Hours
Core Tip
Core Tip: This multicenter study confirms that thermal ablation provides effective local tumor control and meaningful survival benefit in patients with oligometastatic colorectal lung metastases. Importantly, the pattern of extrapulmonary metastasis significantly influences prognosis. Patients with liver-only metastases show comparatively favorable outcomes, underscoring the importance of detailed metastatic pattern assessment in clinical decision-making. Tailoring treatment strategies based on metastatic distribution can optimize patient selection and improve individualized management in oligometastatic colorectal cancer.