Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis
Yan Jia, Yu-Xin Shi, Huan Gu, Ya Liu, Jie Peng, Lu Yan, Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Yan Jia, Yu-Xin Shi, Huan Gu, Ya Liu, Jie Peng, Lu Yan, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Co-first authors: Yan Jia and Yu-Xin Shi.
Author contributions: Jia Y and Shi YX contributed equally to this manuscript and are co-first authors. Jia Y and Shi YX contributed to methodology, formal analysis, and writing original draft; Jia Y and Yan L contributed to conceptualization; Jia Y, Shi YX, and Yan L contributed to writing - review and editing; Jia Y contributed to visualization; Jia Y, Peng J, and Yan L contributed to funding acquisition; Shi YX and Liu Y contributed to software; Gu H contributed to validation; Gu H and Yan L contributed to resources; Gu H and Peng J contributed to investigation; Liu Y contributed to data curation; Peng J and Yan L contributed to project administration; Yan L contributed to supervision.
Supported by Hunan Provincial Natural Science Foundation of China, No. 2022JJ40836; the Key Project of Research and Development Plan of Hunan Province, No. 2023DK2002; and the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation, No. GZC20242045.
Institutional animal care and use committee statement: The animal study protocol was approved by the Experimental Animal Ethics Committee, Xiangya Hospital, Central South University (No. 202110080).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Lu Yan, MD, Department of Gastroenterology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China.
yanluxy@csu.edu.cn
Received: May 16, 2025
Revised: June 26, 2025
Accepted: September 1, 2025
Published online: October 14, 2025
Processing time: 154 Days and 18.6 Hours
