Unraveling the gut-liver axis in autoimmune liver disease overlap syndrome: A multi-omics perspective

doi:10.3748/wjg.v31.i37.112298

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Oct 7, 2025 (publication date) through Sep 28, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Oct 7, 2025; 31(37): 112298
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.112298

Unraveling the gut-liver axis in autoimmune liver disease overlap syndrome: A multi-omics perspective

Eguono D Akpoveta, Uchenna E Okpete, Haewon Byeon

Eguono D Akpoveta, Department of Community Medicine, Federal Medical Centre, Asaba 322022, Delta state, Nigeria

Uchenna E Okpete, Department of Digital Anti-aging Healthcare (BK21), Inje University, Gimhae 50834, Gyeongsangnam-do, South Korea

Haewon Byeon, Worker’s Care and Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, Cheonan 31253, Chungcheongnam-do, South Korea

Co-first authors: Eguono D Akpoveta and Uchenna E Okpete.

Author contributions: Akpoveta ED, Okpete UE and Byeon H contributed to this paper; Byeon H designed the study; Akpoveta ED and Okpete UE were involved in data interpretation, developed the methodology; Akpoveta ED, Okpete UE and Byeon H assisted in writing the article.

Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, No. RS-2023-00237287.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Haewon Byeon, PhD, Associate Professor, Worker’s Care and Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, 1600, Chungjeol-ro, Cheonan 31253, Chungcheongnam-do, South Korea. bhwpuma@naver.com

Received: July 23, 2025
Revised: August 23, 2025
Accepted: September 4, 2025
Published online: October 7, 2025
Processing time: 64 Days and 15.4 Hours

Core Tip

Core Tip: Autoimmune liver disease overlap syndrome, involving features of both primary biliary cholangitis and autoimmune hepatitis, poses diagnostic and therapeutic challenges due to its complex pathophysiology. This letter highlights recent evidence linking gut microbiota alterations and serum metabolite changes to liver function in affected patients. The integration of microbial and metabolic data revealed novel interaction networks that may serve as biomarkers for disease differentiation and progression.