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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2025; 31(36): 110355
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.110355
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.110355
Identification of risk factors for Clostridium difficile infection in older adult hospitalized patients with pressure ulcers
Qin Jiang, Dong-Xin Liu, Wei Lu, Department of Laboratory Medicine, Hangzhou Geriatric Hospital, Hangzhou 310022, Zhejiang Province, China
Hong-Fei Sang, Department of Neurology, Hangzhou Geriatric Hospital, Hangzhou 310022, Zhejiang Province, China
Xiao-Mei Gong, Department of Hospital Infection Control, Hangzhou Geriatric Hospital, Hangzhou 310022, Zhejiang Province, China
Yu-Lei Li, Department of Rehabilitation Medicine, Hangzhou Geriatric Hospital, Hangzhou 310022, Zhejiang Province, China
Author contributions: Jiang Q, Liu DX, and Lu W were responsible for the experimental operation; Sang HF, Gong XM, and Li YL were responsible for the feasibility assessment of the research method, data analysis and interpretation, and core discussion and revision of the conclusion; Jiang Q and Li YL were responsible for the writing and revision of the paper. All the authors participated in the discussion of the results and made revisions to the manuscript.
Supported by the Zhejiang Province Medical and Health Science and Technology Plan Project, No. 2018KY644 and No. 2020KY234.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Hangzhou First People's Hospital (Approval No. 2019182-01).
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request at 502240541@qq.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Lei Li, Nurse Practitioner, Department of Rehabilitation Medicine, Hangzhou Geriatric Hospital, No. 50 Jingshen Street, Gongshu District, Hangzhou 310022, Zhejiang Province, China. 502240541@qq.com
Received: June 11, 2025
Revised: July 31, 2025
Accepted: August 21, 2025
Published online: September 28, 2025
Processing time: 101 Days and 1.2 Hours
Revised: July 31, 2025
Accepted: August 21, 2025
Published online: September 28, 2025
Processing time: 101 Days and 1.2 Hours
Core Tip
Core Tip: This study shows that the incidence of Clostridium difficile infection inolder adult hospitalized patients with pressure ulcers is 32.5%. The use of antibiotics for more than 2 weeks, the use of proton pump inhibitors, and the use of β-lactam antibiotics are independent risk factors, providing important evidence for targeted clinical prevention and control.