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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2025; 31(36): 110210
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.110210
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.110210
Colonic neoplasia and celiac disease: A systematic review
Yasir M Khayyat, Department of Medicine, Faculty of Medicine, Umm AL-Qura University, Makkah 8156-24381, Saudi Arabia
Author contributions: Khayyat YM performed the literature review, collection, initial drafting, and final review of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yasir M Khayyat, FACG, FACP, FRCP (C), Professor, Department of Medicine, Faculty of Medicine, Umm AL-Qura University, AlAwali District, Makkah 8156-24381, Saudi Arabia. ymkhayyat@uqu.edu.sa
Received: June 4, 2025
Revised: June 30, 2025
Accepted: August 27, 2025
Published online: September 28, 2025
Processing time: 110 Days and 21.9 Hours
Revised: June 30, 2025
Accepted: August 27, 2025
Published online: September 28, 2025
Processing time: 110 Days and 21.9 Hours
Core Tip
Core Tip: Celiac disease (CD) involves proinflammatory mechanisms that predispose untreated patients who adhere to a gluten-free diet to the development of neoplastic complications. Gluten peptides have known direct effects on several levels of cell structure, and they increase proinflammatory potential and oncogenesis. Neoplastic complications of the colorectum are considered rare among neoplasms induced by CD. Intestinal lymphoma is a recognized and well-known long-term complication of CD; however, little is known about its role in colorectal cancer. The unfavorable outcomes related to colorectal lymphoma and adenocarcinoma associated with CD require further evaluation to inform possible screening initiatives.