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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2025; 31(36): 109846
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.109846
Published online Sep 28, 2025. doi: 10.3748/wjg.v31.i36.109846
Long-term outcomes of endoscopic resection of 1-1.5 cm sized grade 1 rectal neuroendocrine tumor: A retrospective study
Minjee Kim, Ji Eun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Eun Ran Kim, Department of Medicine, Samsung Medical Center, Seoul 06351, South Korea
Yuwon Kim, Biomedical Statistics Center, Samsung Medical Center, Seoul 06351, South Korea
Author contributions: Kim M, Kim Y, and Kim ER contributed to data analysis and interpretation; Kim M and Kim ER contributed to study design, data acquisition, and final draft of the paper; Kim JE, Hong SN, Chang DK, and Kim YH critically revised the manuscript for important intellectual content. All the authors have read and approved the final manuscript.
Institutional review board statement: The study protocol was reviewed and approved by the Institutional Review Board of Samsung Medical Center (Approval No. SMC 2024-10-073-001). This study was conducted by the principles of the Declaration of Helsinki.
Informed consent statement: Information was only used if patients consented to electronical medical record access. The board exempted informed consent because all data were analyzed anonymously.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data underlying this article cannot be shared publicly due to the privacy of individuals that participated in the study. The data will be shared on reasonable request to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eun Ran Kim, MD, PhD, Department of Medicine, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea. er.kim@samsung.com
Received: May 30, 2025
Revised: June 30, 2025
Accepted: August 26, 2025
Published online: September 28, 2025
Processing time: 114 Days and 5.2 Hours
Revised: June 30, 2025
Accepted: August 26, 2025
Published online: September 28, 2025
Processing time: 114 Days and 5.2 Hours
Core Tip
Core Tip: This study demonstrated that endoscopic resection for 1-1.5 cm well-differentiated rectal neuroendocrine tumors offers clinical outcomes comparable to those for tumors < 1 cm, with high rates of negative margins and no observed recurrence in the intermediate-size group. These findings support the feasibility of endoscopic treatment for 1-1.5 cm rectal neuroendocrine tumors, address a key area of clinical uncertainty, and potentially expand the role of minimally invasive management in this subgroup.