Expanding the genetic landscape of colorectal polyposis: Progress and challenges

doi:10.3748/wjg.v31.i35.112220

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 31, Issue 35

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (0)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-1) series.

Item

Count

PDF

HTML

Figures (1-1)

Tables (1-1)

Sum=0

Sep 21, 2025 (publication date) through Sep 18, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Gastroenterol. Sep 21, 2025; 31(35): 112220
Published online Sep 21, 2025. doi: 10.3748/wjg.v31.i35.112220

Expanding the genetic landscape of colorectal polyposis: Progress and challenges

Arkadeep Dhali, Rick Maity, Jyotirmoy Biswas

Arkadeep Dhali, Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital, Sheffield S5 7AU, United Kingdom

Arkadeep Dhali, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2HQ, United Kingdom

Arkadeep Dhali, Deanery of Clinical Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom

Rick Maity, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India

Jyotirmoy Biswas, Department of General Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata 700058, India

Co-first authors: Arkadeep Dhali and Rick Maity.

Author contributions: Dhali A conceptualized the article and wrote the primary manuscript; Maity R conducted literature review and wrote the primary manuscript; Biswas J wrote the primary manuscript; Dhali A and Maity R have contributed equally to the article and are co-first authors; All authors agreed with the final version of the manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Arkadeep Dhali, MD, Academic Clinical Fellow, Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital, Herries Road, Sheffield S5 7AU, United Kingdom. arkadipdhali@gmail.com

Received: July 21, 2025
Revised: August 24, 2025
Accepted: September 3, 2025
Published online: September 21, 2025
Processing time: 59 Days and 4.6 Hours

Core Tip

Core Tip: This study applies whole-exome sequencing to a Brazilian cohort with unexplained colorectal polyposis, identifying candidate germline variants in 44.4% of patients. The findings highlight the involvement of genes in the Wnt/β-catenin signaling pathway, suggesting biological relevance to colorectal cancer development. Notably, the study addresses the potential for oligogenic inheritance, challenging the traditional monogenic framework for hereditary cancer syndromes. The work emphasizes the need for functional validation, population-specific variant databases, and careful clinical interpretation to translate genetic discoveries into meaningful patient care.