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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2025; 31(34): 110602
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.110602
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.110602
Redefining the albumin-bilirubin score: Predictive modeling and multidimensional integration in liver and systemic disease
Berkay Demirors, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Ramin Shekouhi, Division of Plastic and Reconstructive Surgery, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States
Paola Berrios Jimenez, Department of Surgery, University of Puerto Rico School of Medicine, San Juan 00936, Puerto Rico
Anjali Yadav, Department of General Medicine, Government Medical College and Hospital, Chandigarh, Chandigarh 160030, India
Guido Chiriboga, Mayo Clinic Alix School of Medicine, Jacksonville, FL 32224, United States
Vishal A Mahesh, Department of Surgery, Government Medical College and Hospital, Chandigarh 160030, India
Harsheen K Manaise, Department of General Surgery, University of Connecticut, Hartford, CT 06103, United States
Jade Bowers, College of Medicine, Florida State University, Tallahassee, FL 32304, United States
Angel Aguayo Merly, University of Puerto Rico School of Medicine, San Juan 00936, Puerto Rico
Emmanuel Gabriel, Department of Surgery, Mayo Clinic, Jacksonville, FL 32224, United States
Author contributions: Demirors B conceptualized and designed the study, contributed to literature review, data interpretation, and manuscript drafting; Shekouhi R, Jimenez PB, Yadav A, Chiriboga G, Mahesh VA, Manaise HK, Bowers J, Merly AA contributed to literature review, data interpretation, and manuscript drafting; Gabriel E conceptualized the study, data interpretation and manuscript editing; All authors critically revised the manuscript for important intellectual content and approved the final version for submission.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Berkay Demirors, MD, Postdoctoral Fellow, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, United States. demirorsb2@upmc.edu
Received: June 11, 2025
Revised: July 15, 2025
Accepted: August 14, 2025
Published online: September 14, 2025
Processing time: 87 Days and 15.1 Hours
Revised: July 15, 2025
Accepted: August 14, 2025
Published online: September 14, 2025
Processing time: 87 Days and 15.1 Hours
Core Tip
Core Tip: The albumin-bilirubin score, originally designed for hepatocellular carcinoma, has emerged as an objective, cost-effective liver function assessment tool in non-malignant liver diseases. This editorial discusses its expanding role across cirrhosis, hepatitis, and transplantation, and highlights recent advances that may enhance its clinical utility.