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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2025; 31(34): 108617
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.108617
Published online Sep 14, 2025. doi: 10.3748/wjg.v31.i34.108617
Dopamine receptor D1-mediated suppression of liver fibrosis via Hippo/Yes-associated protein 1 signaling in levodopa treatment
Hai-Yan Wang, School of Medicine, Shanghai University Baoshan Campus, Shanghai 200444, China
Man-Man Qi, Kai Zhang, School of Medicine, Shanghai University, Shanghai 200444, China
Yu-Zhao Zhu, Shanghai Universal Medical Imaging Diagnostic Center, Shanghai 200233, China
Jian Zhang, Department of Nuclear Medicine, Universal Medical Imaging Diagnostic Center, Shanghai University, Shanghai 200233, China
Author contributions: Zhang J and Wang HY designed and performed the experiments, designed the figures and drafted the manuscript; Wang HY designed the experiments, analyzed the data, and critically revised the manuscript for important intellectual content; All authors read and approved the final manuscript; Zhang J and Wang HY confirm the authenticity of all the raw data.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Science and Technology Ethics Committee of Shanghai University (Ethical Review Consent No. ECSHU 2023-103).
Conflict-of-interest statement: The authors declare that they have no competing interests.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Zhang, PhD, Professor, Department of Nuclear Medicine, Universal Medical Imaging Diagnostic Center, Shanghai University, No. 168 Changhai Road, YangPu District, Shanghai 200233, China. abiaoxp@163.com
Received: April 24, 2025
Revised: May 22, 2025
Accepted: August 13, 2025
Published online: September 14, 2025
Processing time: 135 Days and 18.5 Hours
Revised: May 22, 2025
Accepted: August 13, 2025
Published online: September 14, 2025
Processing time: 135 Days and 18.5 Hours
Core Tip
Core Tip: This study found that levodopa significantly alleviated carbon tetrachloride-induced liver fibrosis in rats by upregulating Gα s-coupled protein dopamine receptor D1 (DRD1) expression and enhancing Yes-associated protein 1 (YAP) phosphorylation through the activation of the Hippo signaling pathway. This study for the first time demonstrates levodopa's potential as a novel therapeutic strategy targeting the DRD1-Hippo/YAP axis in liver fibrosis.