Dual therapy with vildagliptin and sacubitril/valsartan alleviates portal hypertension and inhibits soluble epoxide hydrolase in cirrhotic rats
Masafumi Oyama, Kosuke Kaji, Norihisa Nishimura, Junichi Hanatani, Tatsuya Nakatani, Naoki Nishimura, Akihiko Shibamoto, Shohei Asada, Yuki Tsuji, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji
Masafumi Oyama, Kosuke Kaji, Norihisa Nishimura, Junichi Hanatani, Tatsuya Nakatani, Naoki Nishimura, Akihiko Shibamoto, Shohei Asada, Yuki Tsuji, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji, Department of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan
Author contributions: Oyama M contributed to data curation (lead), investigation (lead), formal analysis (lead), methodology (supporting), writing-original draft preparation (lead); Kaji K contributed to conceptualization (lead), data curation (equal), methodology (supporting), resources (equal), supervision (supporting), validation (supporting), visualization (lead), writing-review and editing (lead); Nishimura N contributed to formal analysis (equal), investigation (supporting), writing-review and editing (supporting); Hanatani J, Nakatani T, Nishimura N, Shibamoto A, Asada S contributed to investigation (supporting), writing-review and editing (supporting); Tsuji Y contributed to software (lead), writing-review and editing (supporting); Kitagawa K contributed to formal analysis (supporting), visualization (equal), writing-review and editing (supporting); Sato S contributed to methodology (lead), writing-review and editing (supporting); Namisaki T contributed to supervision (equal), writing-review and editing (supporting); Yoshiji H contributed to conceptualization (equal), resources (lead), supervision (lead), writing-review and editing (equal).
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Nara Medical University, Kashihara, Japan (No. 13502-1).
Institutional animal care and use committee statement: All animal experiments were performed in accordance with the Guide for Care and Use of Laboratory Animals of the National Research Council.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Kosuke Kaji, MD, PhD, Associate Professor, Department of Gastroenterology, Nara Medical University, Shijo-cho 840, Kashihara 634-8522, Nara, Japan.
kajik@naramed-u.ac.jp
Received: May 16, 2025
Revised: June 26, 2025
Accepted: August 7, 2025
Published online: September 7, 2025
Processing time: 109 Days and 2.7 Hours
