Interplay between endocrine disorders and liver dysfunction: Mechanisms of damage and therapeutic approaches

doi:10.3748/wjg.v31.i32.108827

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Aug 28, 2025 (publication date) through Aug 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2025; 31(32): 108827
Published online Aug 28, 2025. doi: 10.3748/wjg.v31.i32.108827

Interplay between endocrine disorders and liver dysfunction: Mechanisms of damage and therapeutic approaches

Andres M Vargas-Beltran, Samantha M Armendariz-Pineda, Froylan D Martínez-Sánchez, Carolina Martinez-Perez, Aldo Torre, Jacqueline Cordova-Gallardo

Andres M Vargas-Beltran, Samantha M Armendariz-Pineda, Carolina Martinez-Perez, Jacqueline Cordova-Gallardo, Department of Hepatology, General Hospital Dr. Manuel Gea Gonzalez, Mexico City 14080, Mexico

Andres M Vargas-Beltran, Faculty of Medicine, Meritorious Autonomous University of Puebla, Puebla 72420, Mexico

Samantha M Armendariz-Pineda, Froylan D Martínez-Sánchez, Jacqueline Cordova-Gallardo, Faculty of Medicine, National University Autonomous of Mexico, Mexico City 04360, Mexico

Froylan D Martínez-Sánchez, Department of Internal Medicine, General Hospital Dr. Manuel Gea Gonzalez, Mexico City 14080, Mexico

Aldo Torre, Department of Gastroenterology, Centro Médico ABC, Mexico City 05300, Mexico

Co-corresponding authors: Aldo Torre and Jacqueline Cordova-Gallardo.

Author contributions: Vargas-Beltran AM, Armendariz-Pineda SM, Martínez-Sánchez FD, Martinez-Perez C wrote the actual manuscript; Vargas-Beltran AM, Martínez-Sánchez FD were responsible for preparing the figures; Torre A, Cordova-Gallardo J revised and polished the manuscript as co-corresponding authors; Vargas-Beltran AM was responsible for the submission of the current version of the manuscript; All authors have read and approved the final manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jacqueline Cordova-Gallardo, MD, Doctor, Faculty of Medicine, National University Autonomous of Mexico, Escolar 411A, Copilco Universidad, Coyoacán, Mexico City 04360, Mexico. jacqueline.cordova@comunidad.unam.mx

Received: April 27, 2025
Revised: June 3, 2025
Accepted: August 1, 2025
Published online: August 28, 2025
Processing time: 123 Days and 5.2 Hours

Core Tip

Core Tip: This review highlights the intricate relationship between endocrine disorders and liver dysfunction, emphasizing the role of hormonal imbalances in the development and progression of liver disease. By examining the effects of thyroid, parathyroid, pancreatic, adrenal, and sex hormones on hepatic metabolism and injury, the article provides a comprehensive overview of pathophysiological mechanisms and emerging therapeutic strategies. Understanding these endocrine-hepatic interactions is essential for early recognition, improved patient management, and the development of targeted treatments in metabolic and chronic liver diseases.