Novel chromogenic medium-based method for the rapid detection of Helicobacter pylori drug resistance

doi:10.3748/wjg.v31.i32.106424

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Aug 28, 2025; 31(32): 106424
Published online Aug 28, 2025. doi: 10.3748/wjg.v31.i32.106424

Novel chromogenic medium-based method for the rapid detection of Helicobacter pylori drug resistance

Ai-Xing Guan, Shuang-Yan Yang, Tong Wu, Wen-Ting Zhou, Hao Chen, Zan-Song Huang, Pei-Pei Luo, Yan-Qiang Huang

Ai-Xing Guan, Zan-Song Huang, Department of Gastroenterology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

Ai-Xing Guan, Zan-Song Huang, Guangxi Clinical Medical Research Center for Hepatobiliary Diseases, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

Shuang-Yan Yang, Department of Rehabilitation Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

Tong Wu, Wen-Ting Zhou, Yan-Qiang Huang, Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

Tong Wu, Wen-Ting Zhou, Yan-Qiang Huang, Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

Tong Wu, Wen-Ting Zhou, Yan-Qiang Huang, Key Laboratory of Prevention and Control to Drug-Resistant Microbial Infection in Guangxi University, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China

Hao Chen, Department of Pathology, Wannan Medical College, Wuhu 241002, Anhui Province, China

Pei-Pei Luo, Department of Gastroenterology, Wujin People’s Hospital Affiliated to Jiangsu University, Changzhou 213004, Jiangsu Province, China

Co-first authors: Ai-Xing Guan and Shuang-Yan Yang.

Co-corresponding authors: Zan-Song Huang and Yan-Qiang Huang.

Author contributions: Guan AX, Yang SY, Wu T, and Zhou WT performed the experiments, acquired and analyzed data; Guan AX and Yang SY contributed equally to this article, they are the co-first authors of this manuscript; Chen H interpreted the data; Huang ZS, Luo PP, and Huang YQ wrote or guided writing the manuscript; Huang ZS and Huang YQ contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors approved the final version of the article.

Supported by the Guangxi Science and Technology Major Projects, No. AA23073012; and the National Natural Science Foundation of China, No. 32360035 and No. 32060018.

Institutional review board statement: This study was approved by the Medical Ethics Committee of Youjiang Medical University.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The datasets generated during this study are fully available within the article and supplementary materials. The relevant data tables and figures are presented in the main text and the supplementary materials.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yan-Qiang Huang, Professor, Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com

Received: April 30, 2025
Revised: May 26, 2025
Accepted: August 1, 2025
Published online: August 28, 2025
Processing time: 118 Days and 16.7 Hours

Core Tip

Core Tip: Helicobacter pylori (H. pylori) drug resistance hinders clinical treatment, with slow, inaccurate detection prolonging therapy and reducing efficacy. This paper presents a novel rapid detection method for H. pylori resistance, identifying it in 28-36 hours - much faster than traditional approaches. It offers high accuracy, reliable resistance assessment, and easy operation, suitable for wide use in clinics and research. This method shows great potential to optimize clinical decisions, improve outcomes, and aid H. pylori infection management.