Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2025; 31(3): 100752
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.100752
Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt: Mechanistic and clinical implications
Qi-Rong Jiang, Da-Wu Zeng
Qi-Rong Jiang, Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Province, China
Da-Wu Zeng, Department of Infectious Diseases, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, Fujian Province, China
Author contributions: Jiang QR was responsible for writing of original draft; Zeng DW was responsible for conceptualization, writing of review and editing.
Supported by Clinical Research Center for Hepatopathy and Intestinal Diseases of Fujian Province, No. 2023GBYJ-YL-1.
Conflict-of-interest statement: Both authors have no financial relationships to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Da-Wu Zeng, MD, Chief Doctor, Department of Infectious Diseases, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou 350004, Fujian Province, China. zengdw1980@fjmu.edu.cn
Received: August 26, 2024
Revised: November 7, 2024
Accepted: November 28, 2024
Published online: January 21, 2025
Processing time: 116 Days and 19.9 Hours
Core Tip

Core Tip: Shifts in gut microbiome composition are closely related to hepatic encephalopathy, yet there is limited research on changes before and after transjugular intrahepatic portosystemic shunt (TIPS) in hepatitis B virus-related portal hypertension patients. The findings by Zhao et al highlight the potential involvement of the bacterial genus Morganella in post-TIPS hepatic encephalopathy. Meanwhile, they also emphasize the importance of the elevation of probiotics in post-TIPS patients without hepatic encephalopathy. Future studies with a larger sample size and a longer evaluation period are needed to address dynamic gut microbiota changes post-TIPS, their correlation with blood ammonia levels, and clinical outcomes.