Comparative analysis of the pathogenesis in Crohn’s disease and ulcerative colitis

doi:10.3748/wjg.v31.i29.109892

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Aug 7, 2025 (publication date) through Feb 26, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2025; 31(29): 109892
Published online Aug 7, 2025. doi: 10.3748/wjg.v31.i29.109892

Comparative analysis of the pathogenesis in Crohn’s disease and ulcerative colitis

Himanshu Agrawal, Nikhil Gupta

Himanshu Agrawal, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Delhi 110095, India

Nikhil Gupta, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India

Author contributions: Agrawal H and Gupta N research conception and design, data acquisition, data analysis and interpretation, drafting of the manuscript, critical revision of the manuscript, supervision, and approval of the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Nikhil Gupta, MS, Professor, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in

Received: May 26, 2025
Revised: June 19, 2025
Accepted: July 14, 2025
Published online: August 7, 2025
Processing time: 73 Days and 1.5 Hours

Core Tip

Core Tip: This article highlights Yang and Zhang’s comprehensive review of Crohn's disease and ulcerative colitis pathogenesis, emphasizing immune dysregulation, genetics, microbiota imbalance, infections, and environmental factors. It underscores the need for personalized therapies, improved diagnostic tools, and longitudinal studies to better understand and manage inflammatory bowel disease.