Agrawal H, Gupta N. Comparative analysis of the pathogenesis in Crohn’s disease and ulcerative colitis. World J Gastroenterol 2025; 31(29): 109892 [DOI: 10.3748/wjg.v31.i29.109892]
Corresponding Author of This Article
Nikhil Gupta, MS, Professor, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 7, 2025; 31(29): 109892 Published online Aug 7, 2025. doi: 10.3748/wjg.v31.i29.109892
Comparative analysis of the pathogenesis in Crohn’s disease and ulcerative colitis
Himanshu Agrawal, Nikhil Gupta
Himanshu Agrawal, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Delhi 110095, India
Nikhil Gupta, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Delhi 110001, India
Author contributions: Agrawal H and Gupta N research conception and design, data acquisition, data analysis and interpretation, drafting of the manuscript, critical revision of the manuscript, supervision, and approval of the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikhil Gupta, MS, Professor, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Received: May 26, 2025 Revised: June 19, 2025 Accepted: July 14, 2025 Published online: August 7, 2025 Processing time: 73 Days and 1.5 Hours
Abstract
This article discusses Yang and Zhang’s review on Crohn’s disease and ulcerative colitis pathogenesis, emphasizing immune dysregulation, genetics, microbiota, and environmental factors. It highlights the need for personalized approaches, longitudinal studies, and better diagnostic tools to improve treatment strategies and patient outcomes in inflammatory bowel disease.
Core Tip: This article highlights Yang and Zhang’s comprehensive review of Crohn's disease and ulcerative colitis pathogenesis, emphasizing immune dysregulation, genetics, microbiota imbalance, infections, and environmental factors. It underscores the need for personalized therapies, improved diagnostic tools, and longitudinal studies to better understand and manage inflammatory bowel disease.
