Goyal O, Goyal MK. Critical analysis of the effects of proton pump inhibitors on inflammatory bowel disease: An updated review. World J Gastroenterol 2024; 30(37): 4160-4162 [PMID: 39474398 DOI: 10.3748/wjg.v30.i37.4160]
Corresponding Author of This Article
Omesh Goyal, DM, MBBS, MD, Professor, Department of Gastroenterology, Dayanand Medical College and Hospital, Civil Lines, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 7, 2024; 30(37): 4160-4162 Published online Oct 7, 2024. doi: 10.3748/wjg.v30.i37.4160
Critical analysis of the effects of proton pump inhibitors on inflammatory bowel disease: An updated review
Omesh Goyal, Manjeet Kumar Goyal
Omesh Goyal, Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Manjeet Kumar Goyal, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India
Author contributions: Goyal O and Goyal MK were responsible for the conceptualization, evidence validation, writing of the original draft, and review and editing of each subsequent version; Goyal O provided overall supervision of the project.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Omesh Goyal, DM, MBBS, MD, Professor, Department of Gastroenterology, Dayanand Medical College and Hospital, Civil Lines, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Received: June 21, 2024 Revised: September 6, 2024 Accepted: September 11, 2024 Published online: October 7, 2024 Processing time: 96 Days and 21 Hours
Core Tip
Core Tip: This letter critically analyzes the review by Liang et al on the effects of proton pump inhibitors (PPIs) on inflammatory bowel disease (IBD), highlighting several methodological flaws. Reliance on cross-sectional and observational studies limits causal inference, and heterogeneous study populations complicate result interpretation. Furthermore, inconsistent definitions of long-term PPI use, inadequate control for confounding factors, and potential publication bias necessitate cautious interpretation. Future research should prioritize large-scale, prospective cohort studies with rigorous control for confounders, standardized outcome measures, and transparent study selection criteria. Addressing these issues is essential for guiding clinical practice effectively and improving outcomes in IBD management.
