Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2024; 30(24): 3059-3075
Published online Jun 28, 2024. doi: 10.3748/wjg.v30.i24.3059
Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer
Zhi-Chang Ba, Xi-Qing Zhu, Zhi-Guo Li, Yuan-Zhou Li
Zhi-Chang Ba, Yuan-Zhou Li, Department of Radiology, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China
Zhi-Chang Ba, Xi-Qing Zhu, Zhi-Chang Ba and Xi-Qing Zhu.
Xi-Qing Zhu, Zhi-Guo Li, Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China
Author contributions: Ba ZX and Zhu XQ contributed equally to this work; Ba ZC contributed to writing of the original draft and review & editing of the manuscript; Ba ZC and Zhu XQ contributed to data curation and investigation; Zhu XQ contributed to methodology and supervision; Li ZG and Li YZ contributed to resources, funding acquisition, and project administration.
Supported by Clinical Research Foundation of Jie-Ping Wu Medical Foundation, No. 320.6750.2022-07-13.
Institutional review board statement: This study was approved by the Ethics Committee of Harbin Medical University Cancer Hospital (No. 2019-57-IIT).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The material supporting the conclusion of this article has been included within the article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan-Zhou Li, PhD, Professor, Department of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China. 830667@hrbmu.edu.cn
Received: April 5, 2024
Revised: May 22, 2024
Accepted: May 29, 2024
Published online: June 28, 2024
Processing time: 81 Days and 8.3 Hours
Core Tip

Core Tip: We conducted a retrospective study in which data for lymphocyte subsets and blood inflammatory markers were collected from 291 patients who underwent surgical treatment for gastric cancer. Least absolute shrinkage and selection operator-COX regression analysis was used to construct a new immune-inflammatory biomarker. Internal validation divided into training and validation sets confirmed that patients with higher prognostic immunoinflammatory index scores had a worse prognosis.