©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2024; 30(1): 34-49
Published online Jan 7, 2024. doi: 10.3748/wjg.v30.i1.34
Published online Jan 7, 2024. doi: 10.3748/wjg.v30.i1.34
Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data
Yu-Wei Zhou, Wei-Xin Cheng, Lin-Ping Ding, Jian-Guo Gao, Juan Du, Chun-Xiao Chen, Xi Jin, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Yue Ren, Department of Gastroenterology, The Second Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China
Miao-Miao Lu, Endoscopy Center, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Ling-Ling Xu, Department of Gastroenterology, The Second People’s Hospital of Yuhang District, Hangzhou 310000, Zhejiang Province, China
Meng-Meng Zhang, Department of Gastroenterology, Hangzhou Shangcheng District People’s Hospital, Hangzhou 310003, Zhejiang Province, China
Dong Chen, Department of Colorectal Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Ci-Liang Jin, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Yun-Fei Li, Tao Cheng, Peng-Fei Xu, Women’s Hospital and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Peng-Lei Jiang, Peng-Xu Qian, Center of Stem Cell and Regenerative Medicine, and Bone Marrow Transplantation Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Yi-Da Yang, Department of Infectious Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Jin X supervised the whole work, generated the concept, and wrote the manuscript; Zhou YW contributed to the writing-original draft, figures, tables, and literature search; Xu PF contributed to the writing-original draft, figures, and literature search; Ren Y, Lu MM, Xu LL, Zhang MM, Cheng WX, Ding LP, Chen D, Gao JG, Jin CL, Du J, Chen CX, Li YF and Cheng T contributed to the literature search; Yang YD, Jiang PL, and Qian PX contributed to the literature search and writing-review.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Xi Jin, MD, PhD, Chief Physician, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn
Received: September 27, 2023
Peer-review started: September 27, 2023
First decision: October 25, 2023
Revised: November 8, 2023
Accepted: December 27, 2023
Article in press: December 27, 2023
Published online: January 7, 2024
Processing time: 101 Days and 3.6 Hours
Peer-review started: September 27, 2023
First decision: October 25, 2023
Revised: November 8, 2023
Accepted: December 27, 2023
Article in press: December 27, 2023
Published online: January 7, 2024
Processing time: 101 Days and 3.6 Hours
Core Tip
Core Tip: The lymphatic system plays an active role in the pathogenesis, progression, and complications of certain diseases. Our review proposes an innovative concept of pan-lymphatic dysfunction and suggests Crohn’s disease (CD) as the intestinal manifestation of pan-lymphatic dysfunction using basic and clinical preliminary data, which may bring new perspectives to both the scientific study and clinical management of CD.