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World J Gastroenterol. Jan 28, 2023; 29(4): 597-615
Published online Jan 28, 2023. doi: 10.3748/wjg.v29.i4.597
Immune and metabolic cross-links in the pathogenesis of comorbid non-alcoholic fatty liver disease
Stanislav Kotlyarov
Stanislav Kotlyarov, Department of Nursing, Ryazan State Medical University, Ryazan 390026, Russia
Author contributions: Kotlyarov S solely contributed to this manuscript.
Conflict-of-interest statement: The author reported no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stanislav Kotlyarov, PhD, Researcher, Department of Nursing, Ryazan State Medical University, Vysokovoltnaya St. 9, Ryazan 390026, Russia. skmr1@yandex.ru
Received: September 19, 2022
Peer-review started: September 19, 2022
First decision: October 22, 2022
Revised: October 28, 2022
Accepted: November 7, 2022
Article in press: November 7, 2022
Published online: January 28, 2023
Processing time: 122 Days and 17.3 Hours
Core Tip

Core Tip: Non-alcoholic fatty liver disease (NAFLD) is an important medical and social problem. The development of NAFLD is closely related to the metabolic syndrome, which further increases attention to the problem. The pathogenesis of NAFLD is complex and involves closely intertwined metabolic and immune mechanisms, a better understanding of which will improve the effectiveness of measures to prevent and treat the disease. Lipid metabolism has multiple connections with the innate immune system, in which various liver cells are involved.