Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2023; 29(31): 4797-4808
Published online Aug 21, 2023. doi: 10.3748/wjg.v29.i31.4797
Circulating copeptin level and the clinical prognosis of patients with chronic liver disease
Hao-Qian Tan, Ming Zhao, Zan Huang, Yang Liu, Han Li, Long-Hui Ma, Jun-Ying Liu
Hao-Qian Tan, Department of Gastroenterology, Zhoukou Central Hospital Affiliated to Xinxiang Medical University, Zhoukou 466000, Henan Province, China
Ming Zhao, Yang Liu, Han Li, Jun-Ying Liu, Department of Gastroenterology, Zhoukou Central Hospital, Zhoukou 466000, Henan Province, China
Zan Huang, Long-Hui Ma, Department of Teaching and Research, Zhoukou Central Hospital, Zhoukou 466000, Henan Province, China
Author contributions: Tan HQ and Liu JY conceived and designed the study; Tan HQ, Zhao M, Huang Z, and Liu Y performed database search, data collection, and study quality evaluation; Tan HQ, Li H, and Ma LH performed statistical analysis; Tan HQ, Zhao M, Huang Z, and Liu JY interpreted the results; Tan HQ wrote the initial draft; all authors revised the manuscript, read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Ying Liu, MD, Director, Department of Gastroenterology, Zhoukou Central Hospital, No. 26 Renmin Road East Section, Chuanhui District, Zhoukou 466000, Henan Province, China. liujunying781025@163.com
Received: June 15, 2023
Peer-review started: June 15, 2023
First decision: July 14, 2023
Revised: July 21, 2023
Accepted: July 28, 2023
Article in press: July 28, 2023
Published online: August 21, 2023
Processing time: 64 Days and 1.8 Hours
Core Tip

Core Tip: Serum copeptin has been related to the severity of circulatory dysfunction and systemic stress response in patients with chronic liver disease (CLD). However, little is known about the relationship between serum copeptin and the prognosis of patients with CLD. In this systematic review and meta-analysis, evidence from ten datasets including 3133 patients were integrated. The results showed that a high level of serum copeptin was associated with a poor transplant-free survival in these patients. These findings support the use of serum copeptin as a prognostic biomarker for patients with CLD.