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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2022; 28(48): 6909-6921
Published online Dec 28, 2022. doi: 10.3748/wjg.v28.i48.6909
Published online Dec 28, 2022. doi: 10.3748/wjg.v28.i48.6909
Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease
Vidyasagar Naik Bukke, Archana Moola, Gaetano Serviddio, Gianluigi Vendemiale, Francesco Bellanti, Department of Medical and Surgical Sciences, University of Foggia, Foggia 71122, Italy
Author contributions: Bukke VN and Moola A collected information for the review and provided a significant contribution in writing the manuscript; The senior authors Serviddio G, Vendemiale G, and Bellanti F drafted and supervised the paper.
Conflict-of-interest statement: All authors declare no conflicts of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Francesco Bellanti, MD, PhD, Associate Professor, Department of Medical and Surgical Sciences, University of Foggia, 1 Viale Pinto, Foggia 71122, Italy.
Received: September 18, 2022
Peer-review started: September 18, 2022
First decision: October 30, 2022
Revised: November 5, 2022
Accepted: November 22, 2022
Article in press: November 22, 2022
Published online: December 28, 2022
Processing time: 99 Days and 20.8 Hours
Peer-review started: September 18, 2022
First decision: October 30, 2022
Revised: November 5, 2022
Accepted: November 22, 2022
Article in press: November 22, 2022
Published online: December 28, 2022
Processing time: 99 Days and 20.8 Hours
Core Tip
Core Tip: This updated literature review contributes to the role of nuclear factor erythroid 2-related factor 2 in combating inflammation, oxidative stress, steatosis, and fibrosis in metabolic associated fatty liver disease. There are several reviews that elucidated the advantages of nuclear factor erythroid 2-related factor 2 in human diseases, but this is the first review reporting the broad range of nuclear factor erythroid 2-related factor 2 modulators and their therapeutic implications in metabolic associated fatty liver disease.