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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2021; 27(39): 6615-6630
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6615
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6615
Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling
Jing-Chun Qin, Yu-Qi Liang, Fei-Fei Nong, Bin Wen, Institute of Science and Technology Inno
Jing-Chun Qin, Liuzhou People’s Hospital, Guangxi, 545006, Guangxi Province China
Wei-Tao Yu, Traditional Chinese Medicine Department, The Second People’s Hospital of Lianyungang, Lianyungang 222000, Jiangsu Province, China
Hui-Xuan Li, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangdong 510000, Guangdong Province, China
Author contributions: Qin JC wrote the manuscript and performed the research; Wen B designed the study; Qin JC, Yu WT, Li HX, and Liang YQ conducted the experiments and analyzed the data; Nong FF reviewed and edited the manuscript; Wen B revised the manuscript.
Supported by National Natural Science Foundation of China , No. 81673944 .
Institutional animal care and use committee statement: The study was reviewed and approved by the Institutional Animal Ethics Committee of the Guangzhou University of Chinese Medicine (approval No. 20130001).
Conflict-of-interest statement: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled “Cold exposure and Capsaicin promote 1,2-dimethylhydrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling”.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wenbin@gzucm.edu.cn. Participants gave informed consent for data sharing.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Wen, PhD, Academic Research, Full Professor, Institute of Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, No. 12 Airport Road, Guangdong 530001, Guangdong Province, China. wenbin@gzucm.edu.cn
Received: March 31, 2021
Peer-review started: April 1, 2021
First decision: June 24, 2021
Revised: July 2, 2021
Accepted: July 30, 2021
Article in press: July 30, 2021
Published online: October 21, 2021
Processing time: 190 Days and 4.6 Hours
Peer-review started: April 1, 2021
First decision: June 24, 2021
Revised: July 2, 2021
Accepted: July 30, 2021
Article in press: July 30, 2021
Published online: October 21, 2021
Processing time: 190 Days and 4.6 Hours
Core Tip
Core Tip: In this study, we discovered that remodeling of extracellular matrix (ECM) plays an important role in the progression of colorectal cancer (CRC). These results suggest that increased stiffness of colonic tissue and the remodeling of ECM mediated by ECM enzymes resulting from cold and capsaicin exposure predisposes an environ