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World J Gastroenterol. Oct 21, 2021; 27(39): 6572-6589
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6572
Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities
Manish Manrai, T V S V G K Tilak, Saurabh Dawra, Sharad Srivastava, Anupam Singh
Manish Manrai, T V S V G K Tilak, Department of Internal Medicine, Armed Forces Medical College, Pune 411040, Maharashtra, India
Saurabh Dawra, Sharad Srivastava, Department of Internal Medicine, Command Hospital, Pune 411040, Maharashtra, India
Anupam Singh, Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh 160011, India
Author contributions: Manrai M conceptualized the review and with Tilak TVSVGK, Dawra S was involved with resources, formal analysis, data curation, writing, review, and editing; Srivastava S was involved with resources and analysis; Singh A was involved with review and editing.
Conflict-of-interest statement: The authors have no conflict-of-interest for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Manish Manrai, MBBS, MD, Professor, Department of Internal Medicine, Armed Forces Medical College, Solapur Road, Pune 411040, Maharashtra, India. manishmanrai@yahoo.com
Received: January 28, 2021
Peer-review started: January 28, 2021
First decision: May 2, 2021
Revised: May 9, 2021
Accepted: August 16, 2021
Article in press: August 16, 2021
Published online: October 21, 2021
Processing time: 264 Days and 13.9 Hours
Core Tip

Core Tip: An improved understanding of the natural history of pancreatic carcinoma, genetics, and tumor biology has highlighted the role of novel therapeutic strategies. However, despite recent advances in the management of pancreatic carcinoma, the prognosis remains poor. We have attempted to conceptualize the current therapeutic strategies in light of recent advances.