Minireviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2021; 27(23): 3262-3278
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3262
Large-duct pattern invasive adenocarcinoma of the pancreas–a variant mimicking pancreatic cystic neoplasms: A minireview
Hiroki Sato, Andrew Scott Liss, Yusuke Mizukami
Hiroki Sato, Yusuke Mizukami, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa 0788510, Hokkaido, Japan
Hiroki Sato, Andrew Scott Liss, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, United States
Yusuke Mizukami, Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo 0650033, Hokkaido, Japan
Author contributions: Sato H wrote and edited the manuscript and collected clinical and pathological data; Mizukami Y reviewed the discussion on pathological findings and genetic alterations in the manuscript; Liss AS revised the manuscript and provided recommendations for the manuscript; all authors have read and approved the final manuscript.
Supported by Japan Society for the Promotion of Science (JSPS) KAKENHI, No. 19K17480 (to Sato H), and No. 20H03655 (Mizukami Y).
Conflict-of-interest statement: There is no conflict of interest associated with any of the authors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiroki Sato, MD, Academic Fellow, Doctor, Research Fellow, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 1-1, Midorigaoka Higashi 2-1, Asahikawa 0788510, Hokkaido, Japan. hirokisato@asahikawa-med.ac.jp
Received: January 28, 2021
Peer-review started: January 28, 2021
First decision: February 24, 2021
Revised: March 9, 2021
Accepted: May 17, 2021
Article in press: May 17, 2021
Published online: June 21, 2021
Processing time: 140 Days and 21.8 Hours
Core Tip

Core Tip: This review integrates the current knowledge about large-duct pattern invasive adenocarcinoma of the pancreas [large-duct pancreatic ductal adenocarcinoma (PDA)]. This subtype is a rare exocrine pancreatic neoplasm and often mimics intraductal papillary mucinous neoplasms (IPMNs). However, its prognosis is notably different from that of IPMNs, and distinguishing this subtype from IPMNs preoperatively is crucial. We summarized the morphological features and genetic landscape of large-duct PDA, with a primary focus on its differences from other types of pancreatic cystic neoplasms. The information aid in making appropriate decisions when tackling atypical pancreatic cystic neoplasms.