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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2021; 27(15): 1569-1577
Published online Apr 21, 2021. doi: 10.3748/wjg.v27.i15.1569
Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
Yuji Sakai, Masayuki Ohtsuka, Harutoshi Sugiyama, Rintaro Mikata, Shin Yasui, Izumi Ohno, Yotaro Iino, Jun Kato, Toshio Tsuyuguchi, Naoya Kato
Yuji Sakai, Harutoshi Sugiyama, Rintaro Mikata, Shin Yasui, Izumi Ohno, Yotaro Iino, Jun Kato, Toshio Tsuyuguchi, Naoya Kato, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Masayuki Ohtsuka, Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Author contributions: Sakai Y, Ohtsuka M, Kato J, Tsuyuguchi T, and Kato N were responsible for manuscript preparation; Sakai Y wrote the paper; Tsuyuguchi T and Kato N revised the manuscript; Sugiyama H, Mikata R, Yasui S, Ohno I, and Iino Y collected the references.
Conflict-of-interest statement: The authors have no other disclosures.
Corresponding author: Yuji Sakai, MD, Doctor, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuou-ku, Chiba 260-8670, Japan. sakai4754@yahoo.co.jp
Received: January 17, 2021
Peer-review started: January 17, 2021
First decision: February 9, 2021
Revised: February 13, 2021
Accepted: March 24, 2021
Article in press: March 24, 2021
Published online: April 21, 2021
Processing time: 87 Days and 0.7 Hours
Core Tip

Core Tip: Intraductal papillary neoplasm of the bile duct (IPNB) is classified into type 1 that is similar to intraductal papillary mucinous neoplasm (IPMN) and type 2 that is not similar to IPMN. Many of IPNB spreads superficially, and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression. Prognosis of IPNB is said to be better than normal bile duct cancer.