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World J Gastroenterol. Apr 21, 2021; 27(15): 1569-1577
Published online Apr 21, 2021. doi: 10.3748/wjg.v27.i15.1569
Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
Yuji Sakai, Masayuki Ohtsuka, Harutoshi Sugiyama, Rintaro Mikata, Shin Yasui, Izumi Ohno, Yotaro Iino, Jun Kato, Toshio Tsuyuguchi, Naoya Kato
Yuji Sakai, Harutoshi Sugiyama, Rintaro Mikata, Shin Yasui, Izumi Ohno, Yotaro Iino, Jun Kato, Toshio Tsuyuguchi, Naoya Kato, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Masayuki Ohtsuka, Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Author contributions: Sakai Y, Ohtsuka M, Kato J, Tsuyuguchi T, and Kato N were responsible for manuscript preparation; Sakai Y wrote the paper; Tsuyuguchi T and Kato N revised the manuscript; Sugiyama H, Mikata R, Yasui S, Ohno I, and Iino Y collected the references.
Conflict-of-interest statement: The authors have no other disclosures.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuji Sakai, MD, Doctor, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuou-ku, Chiba 260-8670, Japan. sakai4754@yahoo.co.jp
Received: January 17, 2021
Peer-review started: January 17, 2021
First decision: February 9, 2021
Revised: February 13, 2021
Accepted: March 24, 2021
Article in press: March 24, 2021
Published online: April 21, 2021
Processing time: 87 Days and 0.7 Hours
Abstract

Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these features, intraductal papillary neoplasm of the bile duct (IPNB), as precancerous lesion of biliary carcinoma. IPNB is currently classified into type 1 that is similar to IPMN, and type 2 that is not similar to IPMN. Many of IPNB spreads superficially, and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression. Prognosis of IPNB is said to be better than normal bile duct cancer.

Keywords: Intraductal papillary neoplasm of the bile duct; Intraductal papillary mucinous neoplasm of the pancreas; Peroral cholangioscopy; Cholangioscopy

Core Tip: Intraductal papillary neoplasm of the bile duct (IPNB) is classified into type 1 that is similar to intraductal papillary mucinous neoplasm (IPMN) and type 2 that is not similar to IPMN. Many of IPNB spreads superficially, and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression. Prognosis of IPNB is said to be better than normal bile duct cancer.