Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2020; 26(8): 804-817
Published online Feb 28, 2020. doi: 10.3748/wjg.v26.i8.804
Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer
Han-Zhang Zhu, Wei-Jiang Zhou, Ya-Feng Wan, Ke Ge, Jun Lu, Chang-Ku Jia
Han-Zhang Zhu, Wei-Jiang Zhou, Ya-Feng Wan, Ke Ge, Jun Lu, Chang-Ku Jia, Department of Hepatopancreatobiliary Surgery, Hangzhou First People’s Hospital, The Affiliated Hospital of Medical School of Zhejiang University. Hangzhou 310006, Zhejiang Province, China
Author contributions: Zhu HZ and Zhou WJ conceived and wrote the manuscript, the two authors contributed equally to the study; Wan YF conducted the data collection; Ge K and Lu J provided the statistical analysis; Jia CK directed the study and revised the manuscript.
Supported by Medicine and Health Science and Technology Plan Projects of Zhejiang Province, No. 2018KY569; and Zhejiang Provincial Natural Science Foundation of China, No. LY17H030002.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Hangzhou First People’s Hospital.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chang-Ku Jia, PhD, Chief Doctor, Department of Hepatopancreatobiliary Surgery, Hangzhou First People’s Hospital, The Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310006, Zhejiang Province, China. jiachk@126.com
Received: November 26, 2019
Peer-review started: November 26, 2019
First decision: December 30, 2019
Revised: January 4, 2020
Accepted: January 11, 2020
Article in press: January 11, 2020
Published online: February 28, 2020
Processing time: 93 Days and 9.7 Hours
Core Tip

Core tip: These studies revealed that ORM genes are specifically expressed in the liver and downregulated in liver tumors. Orosomucoid 2 could be a prognostic factor, and is closely associated with tumor promoter signaling and a immunosuppressive network in liver cancer.