Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol 2020; 26(14): 1601-1612 [PMID: 32327909 DOI: 10.3748/wjg.v26.i14.1601]
Corresponding Author of This Article
Alfredo Di Leo, MD, PhD, Full Professor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. alfredo.dileo@uniba.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol 2020; 26(14): 1601-1612 [PMID: 32327909 DOI: 10.3748/wjg.v26.i14.1601]
World J Gastroenterol. Apr 14, 2020; 26(14): 1601-1612 Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1601
Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model
Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo
Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy
Author contributions: Di Leo A, Ierardi E and Barone M planned the study; Girardi B, Pricci M, Giorgio F, Piazzolla M took care of mice; Girardi B, Pricci M, Giorgio F, Piazzolla M, Losurdo G, Iannone A collected the data; Girardi B, Pricci M, Giorgio F, Piazzolla M performed experimental analysis; Ierardi E and Girardi B performed histological analysis; Iannone A and Losurdo G performed statistical analysis; Girardi B and Ierardi E wrote the paper; All Authors read and approved the final version.
Institutional review board statement: The study protocol was approved by the University of Bari Ethics committee (protocol number 6/12).
Institutional animal care and use committee statement: The study protocol was approved by the University of Bari Committee for Animal Experimentation (protocol number 6/12).
Conflict-of-interest statement: Alfredo Di Leo is an advisory board member of THD S.p.a. Floriana Giorgio, Bruna Girardi and Maria Pricci are employees of THD S.p.a. All the other authors declare no financial support or conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Alfredo Di Leo, MD, PhD, Full Professor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. alfredo.dileo@uniba.it
Received: December 7, 2019 Peer-review started: December 7, 2019 First decision: December 30, 2019 Revised: March 6, 2020 Accepted: March 27, 2020 Article in press: March 27, 2020 Published online: April 14, 2020 Processing time: 125 Days and 20.4 Hours
Core Tip
Core tip: A dietetic formulation containing silymarin, boswellic acid and curcumin has shown “in vitro” and “in vivo” anti-carcinogenetic properties in animal model of inflammation-related intestinal carcinoma. Herein, we assessed whether it may prevent inherited intestinal cancer in animal model (adenomatous polyposis coli multiple intestinal neoplasia - ApcMin/+). Our results showed that the dietetic formulation reduced polypoid lesion number and size on autoptic tissue, histological dysplasia and neoplasia areas. This effect is related to increased epithelial renewal and apoptosis and decreased proliferation. Our data are suggestive of a chemo-preventive synergic effect of the components of the dietetic formulation in inherited intestinal carcinoma.
