D’Antongiovanni V, Pellegrini C, Fornai M, Colucci R, Blandizzi C, Antonioli L, Bernardini N. Intestinal epithelial barrier and neuromuscular compartment in health and disease. World J Gastroenterol 2020; 26(14): 1564-1579 [PMID: 32327906 DOI: 10.3748/wjg.v26.i14.1564]
Corresponding Author of This Article
Matteo Fornai, PharmD, PhD, Assistant Professor, Unit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy. matteo.fornai@unipi.it
Research Domain of This Article
Anatomy & Morphology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Vanessa D’Antongiovanni, Matteo Fornai, Corrado Blandizzi, Luca Antonioli, Nunzia Bernardini, Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy
Carolina Pellegrini, Department of Pharmacy, University of Pisa, Pisa 56126, Italy
Rocchina Colucci, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova 35131, Italy
Author contributions: D’Antongiovanni V and Pellegrini C equally contribute to the manuscript; D’Antongiovanni V, Pellegrini C, Antonioli L, Blandizzi C and Bernardini N conceived the manuscript and contributed to drafting; D’Antongiovanni V, Pellegrini C, Colucci R, Fornai M, Antonioli L, Blandizzi C and Bernardini N contributed to search and selection of abstracts, review of the full length articles and writing the final version of the manuscript. D’Antongiovanni V, Pellegrini C, Colucci R, Fornai M, Antonioli L, Blandizzi C and Bernardini N read and approved the final manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Matteo Fornai, PharmD, PhD, Assistant Professor, Unit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy. matteo.fornai@unipi.it
Received: December 17, 2019 Peer-review started: December 17, 2019 First decision: January 16, 2020 Revised: March 4, 2020 Accepted: March 9, 2020 Article in press: March 9, 2020 Published online: April 14, 2020 Processing time: 118 Days and 23 Hours
Core Tip
Core tip: Current evidence suggests that impairments of intestinal epithelial barrier and enteric neuromuscular compartment might represent a common condition underlying the onset/progression of bowel functional disturbances in both digestive and extra-digestive diseases. In this review, we summarize the impact of morphological and molecular alterations occurring in intestinal epithelial barrier and enteric neuromuscular compartment on bowel motor and secretory functions in digestive and extra-digestive diseases. This assessment, beyond to provide insight on the pathophysiology of bowel motor dysfunctions, could pave the way to the identification of novel therapeutic targets for the management of bowel dysfunctions associated with digestive and extra-digestive disorders.
