Roles of Na+/Ca2+ exchanger 1 in digestive system physiology and pathophysiology

doi:10.3748/wjg.v25.i3.287

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2019; 25(3): 287-299
Published online Jan 21, 2019. doi: 10.3748/wjg.v25.i3.287

Roles of Na⁺/Ca²⁺ exchanger 1 in digestive system physiology and pathophysiology

Qiu-Shi Liao, Qian Du, Jun Lou, Jing-Yu Xu, Rui Xie

Qiu-Shi Liao, Qian Du, Jun Lou, Jing-Yu Xu, Rui Xie, Department of Gastroenterology, Affiliated Hospital to Zunyi Medical College, Zunyi 563000, Guizhou Province, China

Author contributions: Liao QS and Du Q equally contributed to this study, and wrote the manuscript; Liao QS, Du Q, and Lou J participated in information collection, analysis, and organization; Xu JY primarily revised and finalized the manuscript; Xie R revised the manuscript for clarity and style; Xu JY and Xie R are the co-corresponding authors.

Supported by the National Natural Science Foundation of China, No. 816660412 to Xie R and No. 81160265 to Xu JY.

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Rui Xie, MD, PhD, Professor, Department of Gastroenterology, Affiliated Hospital to Zunyi Medical College, No. 149, Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. xr19841029@aliyun.com

Telephone: +86-15120390646 Fax: +86-851-28609205

Received: November 21, 2018
Peer-review started: November 22, 2018
First decision: December 12, 2018
Revised: December 20, 2018
Accepted: December 27, 2018
Article in press: December 27, 2018
Published online: January 21, 2019
Processing time: 61 Days and 16.6 Hours

Core Tip

Core tip: The Na⁺/Ca²⁺ exchange 1 protein (NCX1) is a membrane transporter and participates in the regulation of cellular Ca²⁺ homeostasis. As we known,NCX1 is expressed widely in various organs and tissues and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.