Liao QS, Du Q, Lou J, Xu JY, Xie R. Roles of Na+/Ca2+ exchanger 1 in digestive system physiology and pathophysiology. World J Gastroenterol 2019; 25(3): 287-299 [PMID: 30686898 DOI: 10.3748/wjg.v25.i3.287]
Corresponding Author of This Article
Rui Xie, MD, PhD, Professor, Department of Gastroenterology, Affiliated Hospital to Zunyi Medical College, No. 149, Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. xr19841029@aliyun.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 21, 2019; 25(3): 287-299 Published online Jan 21, 2019. doi: 10.3748/wjg.v25.i3.287
Roles of Na+/Ca2+ exchanger 1 in digestive system physiology and pathophysiology
Qiu-Shi Liao, Qian Du, Jun Lou, Jing-Yu Xu, Rui Xie
Qiu-Shi Liao, Qian Du, Jun Lou, Jing-Yu Xu, Rui Xie, Department of Gastroenterology, Affiliated Hospital to Zunyi Medical College, Zunyi 563000, Guizhou Province, China
Author contributions: Liao QS and Du Q equally contributed to this study, and wrote the manuscript; Liao QS, Du Q, and Lou J participated in information collection, analysis, and organization; Xu JY primarily revised and finalized the manuscript; Xie R revised the manuscript for clarity and style; Xu JY and Xie R are the co-corresponding authors.
Supported bythe National Natural Science Foundation of China, No. 816660412 to Xie R and No. 81160265 to Xu JY.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rui Xie, MD, PhD, Professor, Department of Gastroenterology, Affiliated Hospital to Zunyi Medical College, No. 149, Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. xr19841029@aliyun.com
Telephone: +86-15120390646 Fax: +86-851-28609205
Received: November 21, 2018 Peer-review started: November 22, 2018 First decision: December 12, 2018 Revised: December 20, 2018 Accepted: December 27, 2018 Article in press: December 27, 2018 Published online: January 21, 2019 Processing time: 61 Days and 16.6 Hours
Abstract
The Na+/Ca2+ exchanger (NCX) protein family is a part of the cation/Ca2+ exchanger superfamily and participates in the regulation of cellular Ca2+ homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal absorption. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.
Core tip: The Na+/Ca2+ exchange 1 protein (NCX1) is a membrane transporter and participates in the regulation of cellular Ca2+ homeostasis. As we known,NCX1 is expressed widely in various organs and tissues and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. This review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.
