Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J Gastroenterol 2019; 25(27): 3590-3606 [PMID: 31367159 DOI: 10.3748/wjg.v25.i27.3590]
Corresponding Author of This Article
Jian Qin, MD, PhD, Doctor, Professor, Department of Traditional Chinese Medicine, the Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628, Zhenyuan Road, Guangming New District, Shenzhen 518107, Guangdong Province, China. jian.qin.sunyatsen@outlook.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J Gastroenterol 2019; 25(27): 3590-3606 [PMID: 31367159 DOI: 10.3748/wjg.v25.i27.3590]
Meng-Ting Liu, Ying-Juan Huang, Ting-Ying Zhang, Jian Qin, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Ting-Ying Zhang, Jian Qin, Department of Traditional Chinese Medicine, the Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong Province, China
Lun-Bo Tan, Xi-Feng Lu, Department of Physiology, Shenzhen University Health Science Center, Shenzhen University, Shenzhen 518060, Guangdong Province, China
Author contributions: Qin J, Lu XF, and Liu MT designed the research; Liu MT, Huang YJ, and Zhang TY performed the research and analyzed the data; Liu MT, Qin J, and Tan LB wrote the manuscript; Lu XF extensively revised the manuscript for clarity and grammar.
Supported bythe National Natural Science Foundation of China, No. 81874498.
Institutional review board statement: The study was reviewed and approved by the Seventh Affiliated Hospital of Sun Yat- Sen University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Seventh Affiliated Hospital of Sun Yat-Sen University (2018-057).
Conflict-of-interest statement: The authors declare that there is no conflict of interest to be disclosed.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guideline.
Corresponding author: Jian Qin, MD, PhD, Doctor, Professor, Department of Traditional Chinese Medicine, the Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628, Zhenyuan Road, Guangming New District, Shenzhen 518107, Guangdong Province, China. jian.qin.sunyatsen@outlook.com
Telephone: +86-755-23242725 Fax: +86-755-23242725
Received: March 25, 2019 Peer-review started: March 26, 2019 First decision: May 16, 2019 Revised: May 30, 2019 Accepted: June 8, 2019 Article in press: June 8, 2019 Published online: July 21, 2019 Processing time: 116 Days and 9.1 Hours
Core Tip
Core tip: This study shows that caloric restriction (CR) together with Lingguizhugan decoction (LZD) only slightly reduce body weight and blood glucose levels of normal diet (ND)-fed mice. Yet, transplanting the fecal microbiota of these mice into high-fat diet (HFD)-fed mice potently attenuated diet-induced obesity, hepatic steatosis, and hyperglycemia. Moreover, we found that fecal microbiota transplantation increases oxygen consumption rate of the mice and suppresses hepatic lipid biosynthesis. Using metagenomic sequencing, we further discovered that CR and LZD treatment alters the profile of ND-fed mice, and fecal microbiota transplantation alters HFD-induced changes in gut microbiota. Taken together, our study highlights that CR and LZD treatment exerts its metabolic improving effects via modulating gut microbiota.
