Dimensions of hepatocellular carcinoma phenotypic diversity

doi:10.3748/wjg.v24.i40.4536

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2018; 24(40): 4536-4547
Published online Oct 28, 2018. doi: 10.3748/wjg.v24.i40.4536

Dimensions of hepatocellular carcinoma phenotypic diversity

Romain Désert, Natalia Nieto, Orlando Musso

Romain Désert, Orlando Musso, Institut NuMeCan, Université de Rennes 1, Institut national de la recherche agronomique (INRA), Institut national de la santé et de la recherche médicale (INSERM), Rennes F-35000, France

Romain Désert, Natalia Nieto, Department of Pathology, Department of Medicine (Gastroenterology and Hepatology), University of Illinois at Chicago, IL 60612, United States

Author contributions: Désert R and Musso O designed research; Désert R, Nieto N and Musso O wrote and edited the manuscript; Désert R and Musso O designed figures and tables.

Supported by INSERM (to Musso O); United States Department of Defense Office of the Congressionally Directed Medical Research Programs Grant, No. CA170172 (to Nieto N and Désert R).

Conflict-of-interest statement: The authors have no conflict of interest to declare.

Correspondence to: Orlando Musso, MD, PhD, Senior Scientist, U-1241 Institut NuMeCan, Université de Rennes 1, INRA, INSERM, Nutrition, Métabolismes et Cancer, Hôpital Pontchaillou, rue Henri Le Guilloux, Rennes F-35000, France. orlando.musso@inserm.fr

Telephone: +33-2-23234565 Fax: +33-2-99540137

Received: July 3, 2018
Peer-review started: July 4, 2018
First decision: August 1, 2018
Revised: August 31, 2018
Accepted: October 5, 2018
Article in press: October 5, 2018
Published online: October 28, 2018
Processing time: 118 Days and 14 Hours

Core Tip

Core tip: Recent work revealed substantial steps toward a unifying molecular classification of human hepatocellular carcinomas. The expected translation of high-throughput assays to the clinical practice will further refine evidence-based patient management in terms of prognosis and response to treatment.