Observational Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2018; 24(4): 511-518
Published online Jan 28, 2018. doi: 10.3748/wjg.v24.i4.511
Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines
Yuichiro Kojima, Yosuke Hirotsu, Wataru Omata, Makoto Sugimori, Shinya Takaoka, Hiroshi Ashizawa, Keiko Nakagomi, Dai Yoshimura, Kenji Hosoda, Yoji Suzuki, Hitoshi Mochizuki, Masao Omata
Yuichiro Kojima, Shinya Takaoka, Hiroshi Ashizawa, Keiko Nakagomi, Dai Yoshimura, Kenji Hosoda, Yoji Suzuki, Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Yamanashi 400-8506, Japan
Yosuke Hirotsu, Genome Analysis Center, Yamanashi Prefectural Central Hospital, Yamanashi 400-8506, Japan
Wataru Omata, Department of Dermatologic Oncology, National Cancer Institute, Tokyo 104-0045, Japan
Makoto Sugimori, Division of Gastroenterology, Department of Medicine, Yokohama City University, Graduate School of Medicine, Kanagawa 236-0004, Japan
Hitoshi Mochizuki, Masao Omata, Department of Gastroenterology, Genome Analysis Center, Yamanashi Prefectural Central Hospital, Yamanashi 400-8506, Japan
Author contributions: Kojima Y contributed to writing a paper and data acquisition and most of the patients were in his charge; Hirotsu Y, Omata W, Sugimori M and Takaoka S performed genome analysis; Ashizawa H, Nakagomi K, Yoshimura D, Hosoda K and Suzuki Y contributed to the treatment of patients; Mochizuki H contributed to the data analysis; Omata M contributed to the study conception, design, reviewing and final approval of the article.
Institutional review board statement: The protocol was approved by the Institutional Review Board of Yamanashi Prefectural Central Hospital.
Informed consent statement: Written informed consent to conduct genetic analysis of NUDT15 and TPMT was obtained by all 96 patients.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yuichiro Kojima, MD, PhD, Chief Doctor, Department of Gastroenterology, Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi 400-8506, Japan. y-kojima@ych.pref.yamanashi.jp
Telephone: +81-55-2537111 Fax: +81-55-2538011
Received: October 16, 2017
Peer-review started: October 17, 2017
First decision: November 8, 2017
Revised: December 2, 2017
Accepted: December 5, 2017
Article in press: December 4, 2017
Published online: January 28, 2018
Processing time: 101 Days and 11.2 Hours
Core Tip

Core tip: Single nucleotide polymorphism (SNP) in NUDT15 c.415C>T in exon 3 affects thiopurine-induced leukopenia in Asian Crohn’s disease patients. Meanwhile, there is a report of additional three genetic variants of NUDT15 in patients with acute lymphoblastic leukemia. We evaluated the effect of these additional genetic variants of NUDT15 on inflammatory bowel disease (IBD) treated with thiopurines. The increase rate of mean corpuscular volume was higher in the variants than the wild, Mutations of NUDT15 in exon 1 also affects thiopurine-induced leukopenia in patients with IBD. To discuss thiopurine-induced leukopenia, investigating SNPs both exons 1 and exon 3 of NUDT15 is needed.