Xu WY, Zhang HH, Xiong JP, Yang XB, Bai Y, Lin JZ, Long JY, Zheng YC, Zhao HT, Sang XT. Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients. World J Gastroenterol 2018; 24(29): 3281-3292 [PMID: 30090008 DOI: 10.3748/wjg.v24.i29.3281]
Corresponding Author of This Article
Xin-Ting Sang, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. sangxt@pumch.cn.
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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Xu WY, Zhang HH, Xiong JP, Yang XB, Bai Y, Lin JZ, Long JY, Zheng YC, Zhao HT, Sang XT. Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients. World J Gastroenterol 2018; 24(29): 3281-3292 [PMID: 30090008 DOI: 10.3748/wjg.v24.i29.3281]
World J Gastroenterol. Aug 7, 2018; 24(29): 3281-3292 Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3281
Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients
Wei-Yu Xu, Hao-Hai Zhang, Jian-Ping Xiong, Xiao-Bo Yang, Yi Bai, Jian-Zhen Lin, Jun-Yu Long, Yong-Chang Zheng, Hai-Tao Zhao, Xin-Ting Sang
Wei-Yu Xu, Hao-Hai Zhang, Jian-Ping Xiong, Xiao-Bo Yang, Yi Bai, Jian-Zhen Lin, Jun-Yu Long, Yong-Chang Zheng, Hai-Tao Zhao, Xin-Ting Sang, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: Xu WY conceived the research, collected the clinical data and wrote the manuscript that led to the submission; Xu WY, Zhang HH, and Xiong JP helped to collect the clinical data and followed up with the patients; Lin JZ, Long JY, and Yang XB helped to analyze the data, Bai Y and Zheng YC revised the manuscript, Zhao HT and Sang XT provided financial support for this work; Zhao HT and Sang XT are co-corresponding authors, and they contributed equally to this work; all authors read and approved the final manuscript.
Supported bythe National Key Project Research and Development Projects, No. S2016G9012; International Science and Technology Cooperation Projects, No. 2015DFA30650; and The Capital Special Research Project for Clinical Application, No. Z151100004015170.
Institutional review board statement: The publication of this manuscript has been reviewed and approved by the PUMCH Institutional Review Board.
Informed consent statement: All patients and their families signed informed consent statements before surgery, and the type of surgical procedure was performed according to the approved guidelines.
Conflict-of-interest statement: We declare that the authors have no conflict of interest.
Data sharing statement: No additional data are available.
Correspondence to: Xin-Ting Sang, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. sangxt@pumch.cn.
Telephone: +86-10-69156042 Fax:+86-10-69156042
Received: April 20, 2018 Peer-review started: April 20, 2018 First decision: June 6, 2018 Revised: June 16, 2018 Accepted: June 27, 2018 Article in press: June 27, 2018 Published online: August 7, 2018 Processing time: 105 Days and 4.1 Hours
Core Tip
Core tip: The vital prognostic significance of fibrinogen and serum albumin has been confirmed in diverse malignancies, presenting host hemostasis and nutrition, respectively. Moreover, elevated plasma fibrinogen and reduced serum albumin levels are significantly related to shortened survival of cancer patients. It is reported that fibrinogen-to-albumin ratio (FAR) is more potent in predicting cancer patient prognosis than elevated fibrinogen or reduced serum albumin level alone. Nevertheless, there has been no study on the prognostic role of FAR in gallbladder cancer (GBC). Herein, we defined an elevated preoperative FAR, featured by noninvasiveness, cost-effectiveness and easily-accessible, which was a potential prognostic indicator for GBC.
