Review
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2018; 24(27): 2974-2983
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2974
Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”
Yan-Lan Fang, Hong Chen, Chun-Lin Wang, Li Liang
Yan-Lan Fang, Chun-Lin Wang, Li Liang, Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Hong Chen, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Fang YL primarily analyzed the data and wrote the paper; Chen H collected data and contributed to the writing of the manuscript; Wang CL provided essential analytical tools; Liang L supervised the design and contributed to the writing of the manuscript.
Supported by The National Key Research and Development Program of China, No. 2016YFC1305301.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Li Liang, MD, Chief Doctor, Professor, Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zdliangli@zju.edu.cn
Telephone: +86-571-87235128 Fax: +86-571-87235128
Received: April 13, 2018
Peer-review started: April 13, 2018
First decision: May 9, 2018
Revised: May 26, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: July 21, 2018
Processing time: 97 Days and 15.1 Hours
Core Tip

Core tip: Much work on nonalcoholic fatty liver disease (NAFLD) has been done, but an accurate understanding of its mechanism remains unclear. Our objective was to examine the current literature to better understand the pathogenesis of NAFLD, thus showing how it evolved from the “two-hit theory” to a “multiple hit model”.