©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2018; 24(26): 2878-2885
Published online Jul 14, 2018. doi: 10.3748/wjg.v24.i26.2878
Published online Jul 14, 2018. doi: 10.3748/wjg.v24.i26.2878
Efficacy and safety of endoscopic submucosal tunnel dissection for superficial esophageal squamous cell carcinoma and precancerous lesions
Jin Wang, Xiao-Nan Zhu, Wei Chen, Yi-Han Ma, Tao Gan, Jin-Lin Yang, Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Jin Wang, State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, Sichuan Province, China
Lin-Lin Zhu, Department of General Practice, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wang J, Zhu LL, Gan T and Yang JL designed the research; Wang J, Zhu XN, Zhu LL, Chen W and Ma YH performed the research; Wang J, Zhu XN, Chen W and Ma YH collected the data; Wang J, Zhu LL and Gan T analyzed the data; Wang J, Zhu LL and Yang JL wrote the paper.
Supported by the Science and Technology Department of Sichuan Province for Scientific Research , No. 2015SZ0123 .
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the West China Hospital of Sichuan University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Correspondence to: Jin-Lin Yang, MD, PhD, Chief Doctor, Doctor, MHSc, Professor, Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, 37th Guoxue Alley, Chengdu 610041, Sichuan Province, China. mouse-577@163.com
Telephone: +86-28-85423326 Fax: +86-28-85423326
Received: March 16, 2018
Peer-review started: March 17, 2018
First decision: April 18, 2018
Revised: May 2, 2018
Accepted: June 9, 2018
Article in press: June 9, 2018
Published online: July 14, 2018
Processing time: 118 Days and 11.9 Hours
Peer-review started: March 17, 2018
First decision: April 18, 2018
Revised: May 2, 2018
Accepted: June 9, 2018
Article in press: June 9, 2018
Published online: July 14, 2018
Processing time: 118 Days and 11.9 Hours
Core Tip
Core tip: Endoscopic submucosal tunnel dissection (ESTD) is a modified technique based on endoscopic submucosal dissection. In this paper, we found ESTD is feasible and relatively safe for treating esophageal squamous cell carcinoma (ESCC) and precancerous lesions. The en bloc rate was high, while the adverse event rate was relatively low. When treating large mucosal lesions, ESTD has a high rate of esophageal stricture and positive margin, which requires further treatment. Furthermore, we found that the pathology of preoperative biopsies had to be upgraded after ESTD, which suggests that the accuracy of biopsy to diagnose ESCC should be reconsidered.