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World J Gastroenterol. May 7, 2018; 24(17): 1868-1880
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1868
Anti-integrin therapy for inflammatory bowel disease
Sung Chul Park, Yoon Tae Jeen
Sung Chul Park, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24289, South Korea
Yoon Tae Jeen, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, South Korea
Author contributions: Park SC and Jeen YT wrote the manuscript and made the tables and figures.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yoon Tae Jeen, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, South Korea. ytjeen@korea.ac.kr
Telephone: +82-2-9206555 Fax: +82-2-9531943
Received: March 23, 2018
Peer-review started: March 25, 2018
First decision: April 18, 2018
Revised: April 23, 2018
Accepted: April 26, 2018
Article in press: April 26, 2018
Published online: May 7, 2018
Processing time: 44 Days and 6.3 Hours
Core Tip

Core tip: Anti-integrin therapies have attracted attention as new therapeutic agents in inflammatory bowel disease. They inhibit the extravasation of leukocytes by blocking the interaction between integrins on immune cells and endothelial cell adhesion molecules. The use of the first developed anti-integrin agent, natalizumab is now limited due to the risk of progressive multifocal leukoencephalopathy. However, vedolizumab which acts selectively on the gut has shown few adverse events and is currently used in clinical practice. Newer anti-integrin drugs that act on different integrins-related targets, such as AJM300, abrilumab, etrolizumab, and PF-00547659 have also been developed and are in clinical trials.