Retrospective Cohort Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2017; 23(9): 1608-1617
Published online Mar 7, 2017. doi: 10.3748/wjg.v23.i9.1608
Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study
Thomas M Attard, Mikaela Miller, Chaitanya Pant, Ashwath Kumar, Mike Thomson
Thomas M Attard, Department of Gastroenterology, Children's Mercy Hospital, Kansas, MO 64108, United States
Mikaela Miller, Clinical Decision Support, Children's Mercy Hospital, Kansas, MO 64108, United States
Chaitanya Pant, Department of Gastroenterology, The University of Kansas Hospital, Kansas, KS 66160, United States
Ashwath Kumar, University of Missouri Medical School, Kansas, MO 64108, United States
Mike Thomson, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, United Kingdom
Author contributions: Attard TM and Pant C designed the research; Miller M performed the research; Miller M and Kumar A contributed analytic tools; Attard TM, Miller M and Thomson M wrote the paper.
Institutional review board statement: The study was reviewed and approved for publication by our Institutional Reviewer.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at tmattard@cmh.edu.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Thomas M Attard, MD, Consultant Gastroenterologist, Department of Gastroenterology, Children's Mercy Hospital, Adele Hall, 1605.00, 2401 Gillham Rd, Kansas, MO 64108, United States. tmattard@cmh.edu
Telephone: +1-816-3028149 Fax: +1-816-2341553
Received: September 7, 2016
Peer-review started: September 10, 2016
First decision: October 28, 2016
Revised: November 11, 2016
Accepted: January 2, 2017
Article in press: January 3, 2017
Published online: March 7, 2017
Processing time: 180 Days and 9.1 Hours
Core Tip

Core tip: The management of gastrointestinal haemorrhage in children is challenging insofar as the timing and impact of different interventions remains poorly defined. The authors analysed the characteristics and associated interventions associated with mortality as an outcome with gastrointestinial bleeding in children past infancy. Death associated with gastrointestinal haemorrhage was reported in 2% overall albeit less (0.4%) in the cohort with haemorrhage as admitting diagnosis. Patients who died were far less likely to have undergone endoscopy during the admission and more likely to have received octreotide and less likely to have received proton pump inhibitor therapy during the first two days of admission.