Duan LF, Xu XF, Zhu LJ, Liu F, Zhang XQ, Wu N, Fan JW, Xin JQ, Zhang H. Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis. World J Gastroenterol 2017; 23(40): 7242-7252 [PMID: 29142471 DOI: 10.3748/wjg.v23.i40.7242]
Corresponding Author of This Article
Hong Zhang, MD, PhD, Professor, Department of Pathophysiology, Shaanxi University of Chinese Medicine, Shiji Avenue, Xianyang 712046, Shaanxi Province, China. zhangh1227@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 28, 2017; 23(40): 7242-7252 Published online Oct 28, 2017. doi: 10.3748/wjg.v23.i40.7242
Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis
Li-Fang Duan, Xiao-Fan Xu, Lin-Jia Zhu, Fang Liu, Xiao-Qin Zhang, Nan Wu, Jian-Wei Fan, Jia-Qi Xin, Hong Zhang
Li-Fang Duan, Lin-Jia Zhu, Fang Liu, Xiao-Qin Zhang, Nan Wu, Jian-Wei Fan, Jia-Qi Xin, Hong Zhang, Department of Pathophysiology, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
Xiao-Fan Xu, Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
Author contributions: Zhang H designed the research; Duan LF and Xu XF contributed equally to the work, and both performed most of the experiments and wrote the paper; Zhu LJ, Wu N, Fan JW and Xin JQ performed the experiments; Zhang XQ and Liu F analyzed the data.
Supported by the National Natural Science Foundation of China, No. 81673816; the Key Basic Research Project of Shaanxi Province, No. 2017ZDJC-14; and the Key Research Program of Natural Science of Shaanxi Education Department, No. 15JS027.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Shaanxi University of Chinese Medicine, Xianyang, China.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: No additional data are available.
Correspondence to: Hong Zhang, MD, PhD, Professor, Department of Pathophysiology, Shaanxi University of Chinese Medicine, Shiji Avenue, Xianyang 712046, Shaanxi Province, China. zhangh1227@163.com
Telephone: +86-29-38183453 Fax: +86-29-38183453
Received: July 31, 2017 Peer-review started: August 19, 2017 First decision: September 6, 2017 Revised: September 22, 2017 Accepted: September 29, 2017 Article in press: September 26, 2017 Published online: October 28, 2017 Processing time: 71 Days and 4.2 Hours
Core Tip
Core tip: Macrophages, important inflammatory cells, can also promote fibrogenesis by interfering with the synthesis and degradation of the extracellular matrix, as confirmed in both liver fibrosis and renal fibrosis models. Our study suggested that macrophages also play an important role in the development of pancreatic fibrosis. We found that macrophages are an important source of interleukin-6, which is involved in the progression of chronic pancreatitis (CP). Dachaihu decoction (DCHD), a traditional Chinese medicinal formula, effectively improves the clinical symptoms of CP patients, but the underlying mechanism remains unclear. We found that DCHD ameliorates pancreatic fibrosis by inhibiting macrophage infiltration and inflammatory factor secretion.
