©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2017; 23(35): 6540-6545
Published online Sep 21, 2017. doi: 10.3748/wjg.v23.i35.6540
Published online Sep 21, 2017. doi: 10.3748/wjg.v23.i35.6540
Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection
Shojiro Ichimata, Mikiko Kobayashi, Kohei Honda, Hiroyuki Kanno, Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan
Soichiro Shibata, Akihiro Matsumoto, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan
Author contributions: Ichimata S and Kobayashi M performed the histological evaluation, analyzed the serum sample, and drafted the manuscript; Honda K analyzed the serum sample; Shibata S and Matsumoto A evaluated clinical data; Kanno H performed the histological evaluation, analyzed the serum sample, and critically reviewed the manuscript.
Institutional review board statement: This case report was exempt from the Institutional Review Board standard at Shinshu University School of Medicine.
Informed consent statement: All study participants, or their legal guardian, provided informed consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflict of interest.
Correspondence to: Mikiko Kobayashi, MD, PhD, Department of Pathology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. mikko@shinshu-u.ac.jp
Telephone: +81-263-372607 Fax: +81-263-372609
Received: May 18, 2017
Peer-review started: May 18, 2017
First decision: June 22, 2017
Revised: July 6, 2017
Accepted: August 8, 2017
Article in press: August 8, 2017
Published online: September 21, 2017
Processing time: 127 Days and 5 Hours
Peer-review started: May 18, 2017
First decision: June 22, 2017
Revised: July 6, 2017
Accepted: August 8, 2017
Article in press: August 8, 2017
Published online: September 21, 2017
Processing time: 127 Days and 5 Hours
Core Tip
Core tip: Thrombocytopenia occurs frequently in patients with hepatitis C virus (HCV) infection. Acquired amegakaryocytic thrombocytopenia (AAMT) is one of the causes of severe thrombocytopenia. The exact mechanisms of AAMT have not been fully elucidated. However, patients with autoantibodies to thrombopoietin receptor (c-Mpl) develop AAMT. Similarly, autoantibodies are sometimes generated in patients with HCV infection. Here, we report the first case of a patient with HCV infection who later developed AAMT with autoantibodies to c-Mpl. AAMT with autoantibodies to c-Mpl may be one of the causes of thrombocytopenia in patients with HCV infection.