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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2017; 23(18): 3279-3286
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3279
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3279
Wall shear stress in portal vein of cirrhotic patients with portal hypertension
Wei Wei, Yu Li, Zong-Fang Li, National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Yan-Song Pu, An Jiang, Rui Zhou, Qiu-Juan Zhang, Ya-Juan Wei, Shaanxi Provincial Clinical Research Center for Hepatic and Splenic Diseases, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Xin-Kai Wang, Bin Chen, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi’an 710049, Shaanxi Province, China
Author contributions: Wei W and Pu YS contributed equally to this work; Wei W, Pu YS and Li ZF designed the research; Jiang A, Zhou R, Li Y, Zhang QJ and Wei YJ collected the clinical data; Wang XK and Chen B contributed to the computational fluid dynamics remodeling; Wei W and Pu YS analyzed the data; Wei W and Li ZF wrote the paper.
Supported by the Program for Changjiang Scholars and Innovative Research Team in Universities , No. PCSIRT-1171 ; National Natural Science Foundation of China , No. 81270504 ; Fundamental Research Funds for the Central Universities , No. xjj20100209 .
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of The Second Affiliated Hospital of Xi’an Jiaotong University.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zong-Fang Li, MD, PhD, Professor, National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. lzf2568@gmail.com
Telephone: +86-29-87679508 Fax: +86-29-87678634
Received: December 28, 2016
Peer-review started: December 30, 2016
First decision: January 19, 2017
Revised: February 3, 2017
Accepted: March 3, 2017
Article in press: March 3, 2017
Published online: May 14, 2017
Processing time: 137 Days and 14.3 Hours
Peer-review started: December 30, 2016
First decision: January 19, 2017
Revised: February 3, 2017
Accepted: March 3, 2017
Article in press: March 3, 2017
Published online: May 14, 2017
Processing time: 137 Days and 14.3 Hours
Core Tip
Core tip: For portal hypertension, idealized portal vein (PV) modeling showed a significantly lower wall shear stress (WSS) in both sides of the PV and the occurrence of disturbed flow in the left wall of the PV. In addition, greater risk of disturbed flow was found for smaller PV-splenic vein (SV) angle and larger superior mesenteric vein-SV angle. In patient-specific models, WSS in cirrhotic patients with portal hypertension was markedly lower than that in healthy controls and disturbed flow was more likely to occur in the portal hypertension patients.