Yaghoobi M, McNabb-Baltar J, Bijarchi R, Hunt RH. What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World J Gastroenterol 2017; 23(13): 2435-2442 [PMID: 28428723 DOI: 10.3748/wjg.v23.i13.2435]
Corresponding Author of This Article
Mohammad Yaghoobi, MD, MSc, AFS, FRCPC, Division of Gastroenterology, Division of Gastroenterology, McMaster University, Hamilton, ON L8S 4K1, Canada. yaghoob@mcmaster.ca
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 7, 2017; 23(13): 2435-2442 Published online Apr 7, 2017. doi: 10.3748/wjg.v23.i13.2435
What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis
Mohammad Yaghoobi, Julia McNabb-Baltar, Raheleh Bijarchi, Richard H Hunt
Mohammad Yaghoobi, Richard H Hunt, Division of Gastroenterology, McMaster University, Hamilton, ON L8S 4K1, Canada
Julia McNabb-Baltar, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States
Raheleh Bijarchi, Division of Respirology, Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Richard H Hunt, Division of Gastroenterology, Farncombe Family Digestive Disease Research Institute, Hamilton, ON L8S 4K1, Canada
Author contributions: Yaghoobi M, McNabb-Baltar J and Bijarchi R were responsible for literature search, data gathering, and quality control; Yaghoobi M and Hunt RH were responsible for data analysis and preparation of manuscript.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data is available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mohammad Yaghoobi, MD, MSc, AFS, FRCPC, Division of Gastroenterology, Division of Gastroenterology, McMaster University, Hamilton, ON L8S 4K1, Canada. yaghoob@mcmaster.ca
Telephone: +1-905-5259140
Received: October 30, 2016 Peer-review started: November 2, 2016 First decision: December 19, 2016 Revised: January 17, 2017 Accepted: March 15, 2017 Article in press: March 15, 2017 Published online: April 7, 2017 Processing time: 158 Days and 13.4 Hours
Core Tip
Core tip: Several case-control studies have found a familial predisposition for gastric cancer. Most studies suggest that first-degree relatives of patients with gastric cancer are at higher risk. In this meta-analysis we aimed to quantify this risk by including case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. We showed that the pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35 (95%CI: 1.96-2.81). We concluded that the individuals with a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this high-risk population.
