Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2017; 23(11): 1990-2001
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.1990
Chemotherapy response evaluation in a mouse model of gastric cancer using intravoxel incoherent motion diffusion-weighted MRI and histopathology
Jin Cheng, Yi Wang, Chun-Fang Zhang, He Wang, Wei-Zhen Wu, Feng Pan, Nan Hong, Jie Deng
Jin Cheng, Yi Wang, Wei-Zhen Wu, Feng Pan, Nan Hong, Department of Radiology, Peking University People’s Hospital, Beijing 100044, China
Chun-Fang Zhang, Clinical Epidemiology and Medical Statistics, Peking University People’s Hospital, Beijing 100044, China
He Wang, GE Healthcare, Shanghai 200050, China
Jie Deng, Department of Medical Imaging, Ann and Robert H. Lurie Children’s Hospital of Chicago, Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-2605, United States
Author contributions: Cheng J performed the animal experiments, reviewed the experimental and histological data, and wrote the manuscript; Wang Y designed the entire scientific research, instructed manuscript writing, and revised the manuscript; Zhang CF instructed the statistical analysis; Wang H adjusted the parameters of IVIM-DWI scanning; Wu WZ performed the animal experiments and recorded the experimental data; Pan F performed the animal experiments and recorded the experimental data; Hong N instructed the animal experiments and revised the manuscript; Deng J wrote the Metlab program of the bi-exponential IVIM model and analyzed the IVIM parameter data.
Institutional review board statement: The study was reviewed and approved by the Peking University People’s Hospital Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Peking University People’s Hospital (IACUC protocol number: 2013-0010).
Conflict-of-interest statement: All authors declared that there was no conflict of interest related to this study.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at wangyi@pkuph.edu.cn. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi Wang, MD, Department of Radiology, Peking University People’s Hospital, 11 Xizhimen South St., Beijing 100044, China. wangyi@pkuph.edu.cn
Telephone: +86-10-88325813 Fax: +86-10-68318386
Received: December 22, 2016
Peer-review started: December 23, 2016
First decision: January 10, 2017
Revised: January 19, 2017
Accepted: February 17, 2017
Article in press: February 17, 2017
Published online: March 21, 2017
Processing time: 87 Days and 9.1 Hours
Core Tip

Core tip: In a mouse gastric cancer model, we demonstrated that the intravoxel incoherent motion (IVIM)-derived tissue perfusion coefficient (D*) decreased, whereas perfusion fraction (PF) increased immediately after chemotherapy and during the treatment course. No considerable overlaps were observed in D* and PF measurements between the treated and control groups. IVIM-derived perfusion measurements offer a potential accurate evaluation of chemotherapeutic efficacy. This imaging study is ready to be translated into a clinical study and may facilitate individualized treatment strategy and prompt treatment adjustment in gastric cancer patients.