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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2016; 22(8): 2524-2532
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2524
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2524
Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer
He-Jin Jia, Yu-Lan Liu, Ya-Ping Tian, Core Laboratory of Translational Medicine, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, Beijing 100853, China
Peng-Jun Zhang, Xu Zhu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital & Institute, Beijing 100142, China
Chao-Guang Jiang, The Medical Department of Educational Administration, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Jia HJ, Jiang CG, Zhu X and Tian YP designed the study; Jia HJ and Liu YL performed the research; Jia HJ, Zhang PJ and Tian YP analyzed the data; Jia HJ and Tian YP wrote the paper; Tian YP revised the manuscript for final submission; Jia HJ and Zhang PJ contributed equally to this study; Zhu X and Tian YP are the co-corresponding authors.
Supported by The National High Technology Research and Development Pro-gram 863, NO. 2011AA02A111; The Capital Health Development Special Scientific Research Projects, NO. 2014-2-2154; China Postdoctoral Science Special Foundation Funded Project, NO. 2014T70963; and China Postdoctoral Science Foundation Funded Project, NO. 2013M532110.
Institutional review board statement: The study was reviewed and approved by the Chinese PLA General Hospital Review Board.
Informed consent statement: All study participants or their legal guardians provided written informed consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial or personal relationships with other individuals or organizations that can inappropriately influence our work and that there is no professional or other personal interest of any nature in any product, service and/or company that could be construed as influencing the position presented in or the review of the manuscript.
Data sharing statement: The technical appendix, statistical code, and dataset are available from the corresponding author at tianyp61@gmail.com and drzhuxu@163.com. The study participants provided informed consent for data sharing. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ya-Ping Tian, PhD, MD, Core Laboratory of Translational Medicine, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, 28 Fu-Xing Road, Beijing 100853, China. tianyp61@gmail.com
Telephone: +86-10-66939374 Fax: +86-10-88217385
Received: January 11, 2016
Peer-review started: January 12, 2016
First decision: January 22, 2016
Revised: February 3, 2016
Accepted: February 20, 2016
Article in press: February 20, 2016
Published online: February 28, 2016
Processing time: 44 Days and 22.5 Hours
Peer-review started: January 12, 2016
First decision: January 22, 2016
Revised: February 3, 2016
Accepted: February 20, 2016
Article in press: February 20, 2016
Published online: February 28, 2016
Processing time: 44 Days and 22.5 Hours
Core Tip
Core tip: Serum levels of polyunsaturated fatty acid (PUFA) with interferon gamma (IFN-γ), interleukin-10 (IL-10), IL-6, IL-8, tumor necrosis factor-α, matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9 in colorectal cancer (CRC) were analyzed. IL-6 showed significantly positive association with the C20:4 n-6. IFN-γ showed significant positive association with the C22:5 n-3. IL-8 and MMP-9 showed significant inverse association with the C22:6 n-3. MMP-2 showed significant inverse association with the C20:5 n-3. Our data suggested that nutritional intervention may be related to the inflammation of CRC, and also found that their different role in the regulation of immune response.